Creative Bioarray services

Cell Culture Services: Creative Bioarray Offers Complete Solutions for Your Research Needs

The practice of cell culture remains essential for biomedical research and drug development as it provides critical tools to study cellular functions and disease processes while generating possible treatments. Creative Bioarray utilizes its extensive knowledge and advanced skills in cell culture to deliver a comprehensive suite of services. We provide personalized and dependable high-quality cell culture solutions which help both researchers and companies reach their scientific and therapeutic objectives.

ADME and Pharmacokinetic Services

Creative Bioarray provides various in vitro ADME/PK services including high-throughput ADME screening, in vitro metabolism, in vitro permeability and transporter assays. ADME is short for "absorption, distribution, metabolism, and excretion". The four properties determine the drug level within a body, the drug exposure to tissues, and the metabolic process of a compound, which can help predict the bioavailability and bioactivity of a drug-whether a drug can reach its intended target and confer a therapeutic effect. Therefore, understanding the ADME properties of the compounds is crucial to the drug developing process.

ATP Cell Viability Assay

ATP is involved in a variety of enzymatic reactions to maintain normal life activities. When normal cells undergo apoptosis and necrosis, the content of ATP will be characteristic changed. Thus, ATP has been widely accepted as a valid marker of viable cells. The measurement of ATP using firefly luciferase is the most commonly applied method for estimating the number of viable cells.

creative bioarray - Establishment and Culture Protocol of mESCs Cell Lines

Embryonic stem cells (ESCs) are abbreviated as ES, EK, or ESC cells. They are a class of cells isolated from early embryos (before the proto-intestinal stage) or primitive gonads, which have the properties of unlimited proliferation, self-renewal and multidirectional differentiation in vitro in culture. ES cells can be induced to differentiate into almost all cell types of the organism, both in vitro and in vivo environments.

creative bioarray - FISH Probe Design

With access to the entire RP11 BAC library, Creative Bioarray is capable of developing custom FISH probes. Apart from that, we also offer mRNA ISH/FISH Probes, miRNA ISH/FISH Probes, and lncRNA ISH/FISH Probes. Custom probes can contain up to four fluorescent dyes and can be produced in lot sizes that meet your specific requirements.

creative bioarray - Exosome Identification

Secreted exosomes play important roles in the pathogenesis of various diseases. The quality and purity of isolated exosomes are crucial for their functions and may directly affect the outcome. Creative Bioarray's exosome identification service makes it easy to detect and characterize exosomes with our experience working on exosomes. Our expertise characterizes isolated exosomes in many different ways including particle size, quantity, specific antibodies, and more. We are dedicated to providing our customers with well-developed assays and high-quality data at a competitive price.

creative bioarray - Immortalized Cell Culture

Immortalized cells are a population of cells from a multicellular organism due to mutation, which can escape normal cellular senescence and keep undergoing division. Thus, this kind of cells can grow in vitro for prolonged periods. The mutations required for immortality can occur naturally or be intentionally induced for experimental purposes. Immortal cell lines are a powerful tool for the biological investigator to research the biochemistry and cell biology of multicellular organisms, which plays an important role in the study of the biology of cell growth, differentiation, and senescence. And they have been applied in the research of cell biology, immunology, hematology, cancer biology, toxicology, and molecular biology.

creative bioarray - Microsomal Stability Assay

Creative Bioarray is committed to providing microsomal stability assay service with high effectivity and reliability to accelerate drug development. We provide microsomal stability assays for all small compounds such as pharmaceuticals, industrial chemicals, and clients' products. Creative Bioarray's microsomal stability assay can be further extended to metabolite profiling and give out more information about the metabolism of your compound. S9 stability assay and hepatocyte stability assay are also available at Creative Bioarray. Liver S9 fraction (Cat. CSC-C4093X) as a product can be used in genotoxicity tests such as the Ames test as a metabolic activator.

creative bioarray - Alkaline Phosphatase Staining

Alkaline phosphatase (AP) staining is a rapid method for screening pluripotent cells by using AP activity. AP is a hydrolase responsible for the dephosphorylation of many molecules, such as nucleotides, proteins, and alkaloids under alkaline conditions. AP activity is higher in pluripotent cells but is greatly decreased in more differentiated cell types. The technique described herein may be used to enumerate pluripotent cells during differentiation in the presence or absence of specific genetic manipulations or small chemical modulators. It may also be used to monitor induced pluripotency using defined factors from more differentiated cell types.

creative bioarray - Transgene Mapping

For transgenic cell lines and transgenic animals generated via many methods, the integration site is random and in most cases not known. Integration of a transgene can disrupt an endogenous gene, potentially interfering with interpretation of the phenotype. In addition, knowledge of where the transgene is integrated is important for planning of crosses between animals carrying a conditional allele and a given Cre allele in case the alleles are on the same chromosome.