Profacgen services

Protein is an important source of drug development and industrial enzyme preparation. It is important to reduce side effects and improve the physical and biological properties of engineered proteins. Glycosylation is a common modification of proteins. The process of changing the glycosylation to alter the properties of proteins is known as glycoengineering. The importance of glycoengineering in overcoming the limitations of proteins has been established by research in many disciplines.

The complement system consists of a large number of plasma proteins that assist or complement the ability of phagocytic cells and antibodies to clear pathogens. There are three pathways of complement activation, namely the classical, the alternative and the recently discovered MB-lectin pathway. All three pathways lead to the formation of homologous variants of protease C3 convertase that cleaves C3 to form C3a and C3b. C3b is in turn part of the C5 convertase that cleaves C5 which eventually leads to the formation of the Membrane Attack Complex (MAC) or soluble Terminal Complement Complex, sTCC.

Protein-protein interactions (PPIs) are crucial for understanding signaling cascades, predicting protein biological function, associating proteins with various diseases and insights into drug mechanism of action.

Ubiquitylation is one of the most prevalent post-translational modifications (PTM) within cells. Ubiquitin modification induces protein degradation, which effect on protein function, localization and activity. Therefore, the study of protein ubiquitination plays an important role in cell biology and drug discovery. As a professional PROTAC services provider, Profacgen offers various ubiquitin services to help our customers to accelerate research progress and obtain better results.

Biopharmaceutical products are synthesized by living cells, and hence during the purification process the substrates for growth, host cell components and product variants must be removed.