MedChemExpress - Model Sorbic acid -110-44-1

Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways[1][2][3][4]。

Sorbic acid

MCE China：Sorbic acid

Brand：MedChemExpress (MCE)

Cat. No.HY-N0626

CAS：110-44-1

Purity：99.98%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways。

In Vitro：Sorbic acid (1.0 or 3 mM, 7 days, the pH of the cytoplasm and vacuole was measured between 0 and 400 minutes) inhibits the growth activity of Aspergillus niger by inducing intracellular acidification[4]。

In Vivo：Sorbic acid (0.5-4 g/kg, orally, once daily for 42 days) can improve the growth performance of Duroc × Landrace × Yorkshire piglets by regulating IGF (Insulin-like Growth Factor) system gene expression and hormone secretion[2]. Sorbic acid (1 g/kg, p.o., once daily for 4 weeks) disrupts lipid clearance pathways in C57BL/6 mice (including decreased de novo lipogenesis, fatty acid internalization, very low-density lipoprotein (VLDL) secretion, autophagy, and β-oxidation), leading to hepatic lipid accumulation[3]。

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Liewen MB, et al. Growth and Inhibition of Microorganisms in the Presence of Sorbic Acid: A Review. J Food Prot. 1985 Apr;48(4):364-375. [Content Brief]

[2]. Luo ZF, et al. Sorbic acid improves growth performance and regulates insulin-like growth factor system gene expression in swine. J Anim Sci. 2011 Aug;89(8):2356-64. [Content Brief]

[3]. Chen CH, et al. Food preservative sorbic acid deregulates hepatic fatty acid metabolism. J Food Drug Anal. 2020 Jun 15;28(2):206-216. doi: 10.38212/2224-6614.1055. [Content Brief]

[4]. Plumridge A, et al. The weak acid preservative sorbic acid inhibits conidial germination and mycelial growth of Aspergillus niger through intracellular acidification. Appl Environ Microbiol. 2004 Jun;70(6):3506-11. [Content Brief]

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MedChemExpress - Model Sorbic acid -110-44-1

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Sorbic acid