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MedChemExpress - Model Neostigmine Bromide -114-80-7
MCE products for research use only. We do not sell to patients.
Neostigmine Bromide
MCE China:Neostigmine Bromide
Brand:MedChemExpress (MCE)
Cat. No.HY-B0423
CAS:114-80-7
Synonyms:Eustigmin bromide; Neoserine bromide
Purity:99.91%
Storage:4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Neostigmine (Eustigmin) Bromide is an orally active and reversible cholinesterase inhibitor that acts on myasthenia gravis to prolong and intensify the muscarinic and nicotinic effects of acetylcholine. Neostigmine Bromide can be used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.
In Vivo:Pharmacokinetic parameters of oral tablet and nasal microspheres of Neostigmine Bromide in rabbits[1] Formulation Tmax (h) Cmax (ng/mL) AUC (ng·h/mL) Kel (h-1) T1/2 (h) Oral 1.5 60.07 94.17 0.582 1.19 IN1 3 95.51 446.25 0.164 4.22 IN2 3 90.32 406.85 0.196 3.53
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References:
[2]. Khorshid AF, et al. Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine. Biosens Bioelectron. 2014 Jan 15;51:143-9. [Content Brief]
[3]. SCHWAB RS, et al. Treatment of myasthenia gravis; prolonged action with multiple-dose tablets of neostigmine bromide and mestinon bromide. J Am Med Assoc. 1957 Oct 12;165(6):671-4. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
