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MedChemExpressModel All-trans-retinal -116-31-4

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All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis[1].
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All-trans-retinal

MCE China:All-trans-retinal

Brand:MedChemExpress (MCE)

Cat. No.HY-W004500

CAS:116-31-4

Purity:98.52%

Storage:-20°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.

Shipping:Room temperature in continental US; may vary elsewhere.

Description:All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.

In Vitro:All-trans-retinal (10-30 μM; 16 h) displays a dose-dependent toxicity which included the morphological disruption of ARPE-19 cells and a decrease in their viability is observed to be time-dependent measured by LDH assay[1]. All-trans-retinal (10-30 μM; 30 mim) increases the phosphorylation of p53 at Ser 46 and 8-OHdG production[1].

IC50 & Target:Human Endogenous Metabolite

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References:

[1]. Sawada O, et al. All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis. Exp Eye Res. 2014 Jun;123:27-36.  [Content Brief]

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