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Dimethyl phthalate

MCE China：Dimethyl phthalate

Brand：MedChemExpress (MCE)

Cat. No.HY-N7106

CAS：131-11-3

Synonyms：DMP

Purity：99.95%

Storage：RT, protect from light In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats.

In Vitro：Dimethyl phthalate (0.39 or 1.5625 mM, 24 hours) promotes oxidative stress and apoptosis in SH-SY5Y cells[2]. Dimethyl phthalate (5-80 mg/L, 5.5 hours) causes membrane damage in Escherichia coli K12 cells, increasing membrane permeability, promoting cell death, and inducing oxidative stress[3].

In Vivo：Dimethyl phthalate (50-1000 mg/kg, p.o., once daily for 7 days) affects rat blood and red blood cell function by inducing oxidative stress, as evidenced by a significant increase in malondialdehyde (MDA) levels and elevated iron release[4]. Dimethyl phthalate (0.5, 1, 2 g/kg, p.o., once daily for 20 or 40 days) significantly affects ovarian function in C57BL/6J mice, leading to a decrease in follicle-stimulating hormone (FSH), an increase in estradiol (E2) and luteinizing hormone (LH), and ovarian cell apoptosis[5].

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References：

[1]. Wang ZG, et al. Impacts of dimethyl phthalate on the bacterial community and functions in black soils. Front Microbiol. 2015 May 5;6:405.  [Content Brief]

[2]. Kara M, et al. Investigation of the Neurotoxic Effects of Dimethyl Phthalate and Diisobutyl Phthalate on SH-SY5Y Neuroblastoma Cells[J]. Recent Trends in Pharmacology, 2024, 2(3): 101-108.

[3]. Wang Z, et al. Dimethyl phthalate damaged the cell membrane of Escherichia coli K12. Ecotoxicol Environ Saf. 2019 Sep 30;180:208-214.  [Content Brief]

[4]. Chi Z, et al. Revealing the toxicity of dimethyl phthalate (DMP) to the oxygen-carrying function of red blood cells (RBCs): The iron release mechanism. Chemosphere. 2021 Jan;263:128017.  [Content Brief]

[5]. Mei Y, et al. Effects of Dimethyl Phthalate (DMP) on Serum Sex Hormone Levels and Apoptosis in C57 Female Mice. Int J Endocrinol Metab. 2019 Apr 22;17(2):e82882.  [Content Brief]

[6]. Yin H, et al. Dimethyl phthalate exposure induces cognitive impairment via COX2-mediated neuroinflammation. Ecotoxicol Environ Saf. 2024 Oct 1;284:117039.  [Content Brief]