MedChemExpress - Model Penicillin V Potassium -132-98-9

Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4].

Penicillin V Potassium

MCE China：Penicillin V Potassium

Brand：MedChemExpress (MCE)

Cat. No.HY-B0975

CAS：132-98-9

Synonyms：Phenoxymethylpenicillin potassium salt

Purity：99.01%

Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.

In Vitro：Penicillin V (0.002-8.0 mg/L) inhibits the growth of Streptococci, with the minimum inhibitory concentrations (MICs) of 0.004-0.008 mg/L[2]. Penicillin V (0.002-8.0 mg/L) inhibits the growth of C. difficile, with a MIC90 of 8 mg/L[3]. Penicillin V (0.004-0.063 mg/L; 18 h) inhibits the growth of Staphylococcus aureus, with a MIC of 0.016 mg/L[4].

In Vivo：Penicillin V (0.063-0.25 mg/kg; a single s.c.) inhibits the outgrowth of S. aureus in mice thigh muscle[4]. Penicillin V (100 mg/kg; p.o. once daily for 5 d) avoids the fulminant infection of acute purulent otitis media (AOM) in rats[5]. Penicillin V (2 mg/kg; a single s.c.) exhibits the plasma half-life (61 min) and mean AUC (0.47 mg/L•h)[4][4].

IC50 & Target：β-lactam

References：

[1]. Sabath LD. Et, al. Phenoxymethylpenicillin (penicillin V) and phenethicillin. Med Clin North Am. 1970 Sep;54(5):1101-11. [Content Brief]

[2]. Kamme C, et, al. In vitro effect on group A streptococci of loracarbef versus cefadroxil, cefaclor and penicillin V. Scand J Infect Dis. 1993;25(1):37-42. [Content Brief]

[3]. Norén T, et, al. In vitro susceptibility to 17 antimicrobials of clinical Clostridium difficile isolates collected in 1993-2007 in Sweden. Clin Microbiol Infect. 2010 Aug;16(8):1104-10. [Content Brief]

[4]. Overbosch D, et, al. Comparative pharmacodynamics and clinical pharmacokinetics of phenoxymethylpenicillin and pheneticillin. Br J Clin Pharmacol. 1985 May;19(5):657-68. [Content Brief]

[5]. Hermansson A, et, al. Prevention of experimental acute otitis media with penicillin V. Acta Otolaryngol. Jan-Feb 1990;109(1-2):119-23. [Content Brief]

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MedChemExpress - Model Penicillin V Potassium -132-98-9

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Penicillin V Potassium