MedChemExpress - Model 5-Methyltetrahydrofolic acid -134-35-0
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5-Methyltetrahydrofolic acid
MCE China：5-Methyltetrahydrofolic acid
Brand：MedChemExpress (MCE)
Cat. No.HY-113046
CAS：134-35-0
Synonyms：5-Methyl THF; 5-MTHF
Purity：99.77%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases.
In Vitro：5-Methyltetrahydrofolic acid (0, 10, 50 and 100 μM; 24 h) increases the production of ET-1 in endothelial cells in a concentration-dependent manner[2]. 5-Methyltetrahydrofolic acid (100 μM; 24 h) inhibits the production of thiobarbituric acid reactive substances (TBARS) by HUVEC in the presence of low-density lipoprotein[2].
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. Wright AJ, et al. Comparison of (6 S)-5-methyltetrahydrofolic acid v. folic acid as the reference folate in longer-term human dietary intervention studies assessing the relative bioavailability of natural food folates: comparative changes in folate status following a 16-week placebo-controlled study in healthy adults. Br J Nutr. 2010 Mar;103(5):724-9. [Content Brief]
[2]. Ronco, et al. "5-methyltetrahydrofolic acid stimulates endothelin-1 production in low density lipoprotein-treated human endothelial cells." Nutrition, Metabolism and Cardiovascular Diseases 17.3 (2007): 188-194. [Content Brief]
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