MedChemExpress - Model Amprolium hydrochloride -137-88-2
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Amprolium hydrochloride
MCE China：Amprolium hydrochloride
Brand：MedChemExpress (MCE)
Cat. No.HY-B0937A
CAS：137-88-2
Purity：98.79%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Amprolium hydrochloride is an anti-parasitic drug that's kind of taken orally, and it acts as an antagonist to thiamine in intestinal absorption.
In Vivo：Amprolium hydrochloride (1 g/L, oral, daily, for 7 days) can be used as a preventive measure in rabbits in combination with other anti-coccidial drugs[1]. Amprolium hydrochloride (8 mg-2 g, taken orally or injected subcutaneously, daily, for 4-34 days) exerts an antagonistic effect with thiamine primarily at the level of the intestinal epithelial cells, impacting thiamine absorption. Once administered directly bypassing the gut, it does not significantly affect thiamine's entry into other tissue cells[2].
IC50 & Target：Coccidia
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References：
[1]. Kennedy O Ogolla, et al. Efficacy of Sulphachloropyrazine, Amprolium Hydrochloride, Trimethoprim-Sulphamethoxazole, and Diclazuril against Experimental and Natural Rabbit Coccidiosis. J Vet Med. 2018 Oct 23:2018:5402469. [Content Brief]
[2]. G Rindi, et al. Action of Amprolium on the thiamine content of rat tissues. J Nutr. 1966 Jun;89(2):197-202. [Content Brief]
[3]. Iqbal A, et al. Antiparasitic efficacy of Artemisia absinthium, toltrazuril and amprolium against intestinal coccidiosis in goats. J Parasit Dis. 2013 Apr;37(1):88-93. [Content Brief]
[4]. Lindsay DS, et al. Effects of sulfadiazine and amprolium on Neospora caninum (Protozoa: Apicomplexa) infections in mice. J Parasitol. 1990 Apr;76(2):177-9. [Content Brief]
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