MedChemExpress - Model Pyraclostrobin -175013-18-0

Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases[1][2][3].

Pyraclostrobin

MCE China：Pyraclostrobin

Brand：MedChemExpress (MCE)

Cat. No.HY-N6626

CAS：175013-18-0

Purity：99.91%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases.

In Vitro：Pyraclostrobin (10-80 μmol/L, 24 h) exhibits toxic effects in HepG2 cells[1]. Pyraclostrobin (10-80 μmol/L, 6 h) induced DNA damage and mitochondrial dysfunction in HepG2 cells[1].

In Vivo：Pyraclostrobin (0.01-0.08 μmol/L, Zebrafish larvae were subjected to pyraclostrobin exposure persisting until 72 h post fertilization) results in hepatomegaly in zebrafish larvae[1]. Pyraclostrobin (0.001-0.02 mg/L, Fish were assigned to a vessel containing 20 L of water dissolved Pyraclostrobin for 7-28 days) has the toxic effects on DNA damage and antioxidant enzymatic activities in the zebrafish liver[2]. Pyraclostrobin (33-48 μg/L, Zebrafish larvae at 4 days post fertilization (dpf) were transferred into 24-well plates and subjected to pyraclostrobin until 8 dpf) has toxic effects on zebrafish larvae[3].

IC50 & Target：Bax Bcl-2

References：

[1]. Wu M, et al. Characterization of hepatotoxic effects induced by pyraclostrobin in human HepG2 cells and zebrafish larvae [J]. Chemosphere, 2023, 340: 139732. [Content Brief]

[2]. Zhang C, et al. Acute and subchronic toxicity of pyraclostrobin in zebrafish (Danio rerio) [J]. Chemosphere, 2017, 188: 510-516. [Content Brief]

[3]. Li H, et al. Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae [J]. Environmental Pollution, 2019, 251: 203-211. [Content Brief]

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MedChemExpress - Model Pyraclostrobin -175013-18-0

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Pyraclostrobin