MedChemExpress - Model 5A2-SC8 -1857341-90-2
MCE products for research use only. We do not sell to patients.
5A2-SC8
MCE China：5A2-SC8
Brand：MedChemExpress (MCE)
Cat. No.HY-145799
CAS：1857341-90-2
Purity：99.19%
Storage：-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：5A2-SC8 is an ionizable amino lipid in lipid nanoparticles (LNPs) that shows high delivery potential and low in vivo toxicity, enabling efficient delivery of small RNAs such as siRNA and miRNA into tumor cells. 5A2-SC8 LNPs can confer a unique delivery fate of RNA within the liver, thereby changing the therapeutic outcomes in cancer models.
In Vitro：The ApoE protein corona adsorbs on the surface of 5A2-SC8 LNPs binds to LDL-R on the surface of hepatocytes and undergoes receptor-mediated endocytosis, and is taken up by hepatocytes[2].
In Vivo：5A2-SC8 (75 mg/kg; i.v.; single-dose) is well tolerated and does not affect survival in mice with chronic aggressive hepatocellular carcinoma[1]. 5A2-SC8 (0.5 mg/kg; i.v.; single-dose) can pass the first barrier of Kupffer cells in the liver and be internalized into hepatocytes in the presence of siFVII labeled with Cy5.5 dye[2].
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References：
[1]. Zhou K, Nguyen LH, Miller JB, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016;113(3):520-525. [Content Brief]
[2]. Johnson, et al. "Lipid nanoparticle (LNP) chemistry can endow unique in vivo RNA delivery fates within the liver that alter therapeutic outcomes in a cancer model." Molecular pharmaceutics 19.11 (2022): 3973-3986. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。