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MedChemExpress - Model CC-90002 -2085844-54-6
MCE products for research use only. We do not sell to patients.
CC-90002
MCE China:CC-90002
Brand:MedChemExpress (MCE)
Cat. No.HY-P99172
CAS:2085844-54-6
Purity:97.97%
Storage:Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping:Shipping with dry ice.
Description:CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar Kd value. CC-90002 can be used for the research of hematologic malignancies and solid tumors.
In Vitro:CC-90002 has a high affinity for binding to CD47 with a subnanomolar dissociation constant (Kd) value[1]. CC-90002 can block the CD47-SIRPa interaction with IC50 value in the subnanomolar range[1]. CC-90002 has inhibitory effect in concentration-dependent in the ALL and AML cell lines[1].
In Vivo:CC-90002 shows significant dose-dependent antitumor activity and significant tumor regression in tumor xenografts models[1].
Species:Humanized
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References:
[2]. Zhongxing Jiang, et al. Targeting CD47 for cancer immunotherapy. J Hematol Oncol. 2021 Oct 30;14(1):180. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
