MedChemExpress - Model Carbimazole -22232-54-8

Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research[1][2][3].

Carbimazole

MCE China：Carbimazole

Brand：MedChemExpress (MCE)

Cat. No.HY-B0558

CAS：22232-54-8

Purity：98.0%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.

In Vitro：Carbimazole (0.01-2 mM, 6 h) inhibits the global translation of protein in SK-N-SH cells[1]. Carbimazole (0.5 mM, 12-72 h) inhibits hypoxic SK-N-SH cell injury and preserve intracellular ATP content in an oxygen-free atmosphere through inhibiting protein synthesis and activating MAPK[1].

In Vivo：Carbimazole (10, 15, 20 mg/animal/day, p.o., 21 d) shows mainly dose-dependent responses of basic physiological parameters in rabbits[2].

References：

[1]. Lehane C, et al. Carbimazole is an inhibitor of protein synthesis and protects from neuronal hypoxic damage in vitro. J Pharmacol Exp Ther. 2013 Dec;347(3):781-93. [Content Brief]

[2]. H. Saeed, et al. Effects of Dose Level of Anti-thyroid Drug Carbimazole on Thermoregulation and Blood Constituents in Male Rabbits (Oryctolagus cuniculus). Advances in Research, 2014, 2(3), 129–144.

[3]. Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10(6): p. 637-48. [Content Brief]

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MedChemExpress - Model Carbimazole -22232-54-8

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Carbimazole