MedChemExpress - Model 4-Nitrophenyl ß-D-glucopyranoside -2492-87-7

4-Nitrophenyl β-D-glucopyranoside is a chromogenic substrate for β-glucosidase. 4-Nitrophenyl β-D-glucopyranoside is converted to a colored product, p-nitrophenol that is easily detected spectrophotometrically at 405 nm when used in a β-glycosidase assay. 4-Nitrophenyl β-D-glucopyranoside is hydrolysed through intramolecular nucleophilic catalysis by the phosphate group in the 2-position. 4-Nitrophenyl β-D-glucopyranoside is promising for research of postmenopausal osteoporosis[1][2][3].

4-Nitrophenyl β-D-glucopyranoside

MCE China：4-Nitrophenyl β-D-glucopyranoside

Brand：MedChemExpress (MCE)

Cat. No.HY-15927

CAS：2492-87-7

Purity：99.69%

Storage：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：4-Nitrophenyl β-D-glucopyranoside is a chromogenic substrate for β-glucosidase. 4-Nitrophenyl β-D-glucopyranoside is converted to a colored product, p-nitrophenol that is easily detected spectrophotometrically at 405 nm when used in a β-glycosidase assay. 4-Nitrophenyl β-D-glucopyranoside is hydrolysed through intramolecular nucleophilic catalysis by the phosphate group in the 2-position. 4-Nitrophenyl β-D-glucopyranoside is promising for research of postmenopausal osteoporosis.

In Vitro：4-Nitrophenyl β-D-glucopyranoside (1-20 μM) shows 17%-19% inhibitory effects on adipogenesis at 20 µM treatment in mouse mesenchymal stem cell lines[3].

References：

[1]. Alhifthi A, et al. Unimolecular, Bimolecular, and Intramolecular Hydrolysis Mechanisms of 4-Nitrophenyl β-d-Glucopyranoside. J Org Chem. 2021 Jul 16;86(14):9530-9539. [Content Brief]

[2]. Lee KH, et al. Ginkgonitroside, a new nitrophenyl glycoside and bioactive compounds from Ginkgo biloba leaves controlling adipocyte and osteoblast differentiation. Bioorg Med Chem Lett. 2021 Oct 15;50:128322. [Content Brief]

[3]. Rosie F D. Nucleophilic catalysis of glycoside hydrolysis. The hydrolysis of 4-nitrophenyl α-and β-D-glucopyranoside tetraphosphates[J]. Journal of the Chemical Society, Perkin Transactions 2, 1994 (10): 2085-2090.

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MedChemExpress - Model 4-Nitrophenyl ß-D-glucopyranoside -2492-87-7

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4-Nitrophenyl β-D-glucopyranoside