MedChemExpress - Model 2-Thenoyltrifluoroacetone -326-91-0

2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases[1][2][3].

2-Thenoyltrifluoroacetone

MCE China：2-Thenoyltrifluoroacetone

Brand：MedChemExpress (MCE)

Cat. No.HY-D0190

CAS：326-91-0

Synonyms：HTTA; TTA; TTFA

Purity：99.96%

Storage：4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases[1][2][3].

In Vitro：2-Thenoyltrifluoroacetone (100-1000μM, 24 h) increases mitochondrial ROS production and induces microglial cell activation by inhibiting mitochondrial electron transport chain[1]. 2-Thenoyltrifluoroacetone (28.2-51.5 μM, 72 h) exhibits cytotoxicity and anticancer activity on K562 cells by forming a complex with copper (II) [2]. 2-Thenoyltrifluoroacetone (500, 750, 1000 ng/mL, 24, 48, 72 h) exhibits cytotoxicity and anti-tumor activity against MCF-7 and MKN-45 cells by forming a complex with zinc (II) [3]. 2-Thenoyltrifluoroacetone (1-25 μM, 20 min) significantly inhibits carboxylesterase activity in rat plasma and mitochondria [4].

IC50 & Target：IC50: 51.5 μM (mitochondrial electron transport chain)[1]. IC50: 0.54 μM (carboxylesterase)[4]. In Vitro 2-Thenoyltrifluoroacetone (100-1000μM, 24 h) increases mitochondrial ROS production and induces microglial cell activation by inhibiting mitochondrial electron transport chain[1]. 2-Thenoyltrifluoroacetone (28.2-51.5 μM, 72 h) exhibits cytotoxicity and anticancer activity on K562 cells by forming a complex with copper (II) [2]. 2-Thenoyltrifluoroacetone (500, 750, 1000 ng/mL, 24, 48, 72 h) exhibits cytotoxicity and anti-tumor activity against MCF-7 and MKN-45 cells by forming a complex with zinc (II) [3]. 2-Thenoyltrifluoroacetone (1-25 μM, 20 min) significantly inhibits carboxylesterase activity in rat plasma and mitochondria [4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 2-Thenoyltrifluoroacetone Related Antibodies Cell Viability Assay[1]. Cell Line: microglial cell

References：

[1]. Ye J, et al. Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production. Exp Cell Res. 2016 Jan 15;340(2):315-26. [Content Brief]

[2]. P.S. Lopes, et al. A new copper(II) complex with 2-thenoyltrifluoroacetone and 2,2-bipyridine: Crystal structure, spectral properties and cytotoxic activity. Journal of Molecular Structure. J. Mol. Struct. 2013. 1034:84-88.

[3]. Rahime Eshaghi Malekshah, et al. Crystal structure, molecular docking, and biological activity of the zinc complexes with 2-thenoyltrifluoroacetone and N-donor heterocyclic ligands. J. Mol. Struct. 2017. 1150:155-165

[4]. Zhang JG, et al. Thenoyltrifluoroacetone, a potent inhibitor of carboxylesterase activity. Biochem Pharmacol. 2002 Feb 15;63(4):751-4. [Content Brief]

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MedChemExpress - Model 2-Thenoyltrifluoroacetone -326-91-0

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2-Thenoyltrifluoroacetone