MedChemExpress - Model GSK3-IN-3 -331963-27-0

GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA[1][2][3].

GSK3-IN-3

MCE China：GSK3-IN-3

Brand：MedChemExpress (MCE)

Cat. No.HY-153089

CAS：331963-27-0

Purity：98.80%

Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：GSK3-IN-3 is a mitophagy inducer, inducing Parkin-dependent mitophagy. GSK3-IN-3 is also a GSK-3 inhibitor with an IC50 value of 3.01 μM. GSK3-IN-3 is non-ATP nor substrate competitive and is neuroprotective against 6-OHDA.

In Vitro：GSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells with restricted potency[1]. GSK3-IN-3 (1.56-25 μM; 24 h) results in mitochondria fission with mitochondrial morphology change in U2OS-iMLS-Parkin cells[1]. GSK3-IN-3 (VP0.7) (5 μM, 10 μM; ) shows neuroprotection against 6-OHDA albeit in a Parkinson's disease in vitro cellular model in SH-SY5Y cells[2].

IC50 & Target：IC50: 3.01 μM (GSK-3)[3] In Vitro GSK3-IN-3 (VP07) (25 μM; 24 h) induces mitophagy in Parkin-expressing U2OS-iMLS cells with restricted potency[1]. GSK3-IN-3 (1.56-25 μM; 24 h) results in mitochondria fission with mitochondrial morphology change in U2OS-iMLS-Parkin cells[1]. GSK3-IN-3 (VP0.7) (5 μM, 10 μM; ) shows neuroprotection against 6-OHDA albeit in a Parkinson's disease in vitro cellular model in SH-SY5Y cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> GSK3-IN-3 Related Antibodies Immunofluorescence[1] Cell Line: Parkin-expressing U2OS-iMLS cells

References：

[1]. Maestro I, et al. Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease. ACS Chem Neurosci. 2021 Dec 15;12(24):4512-4523. [Content Brief]

[2]. Morales-García JA, et al. Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease. ACS Chem Neurosci. 2013 Feb 20;4(2):350-60. [Content Brief]

[3]. Palomo V, et al. Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities. J Med Chem. 2011 Dec 22;54(24):8461-70. [Content Brief]

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MedChemExpress - Model GSK3-IN-3 -331963-27-0

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GSK3-IN-3