MedChemExpress - Model Methyl p-coumarate -3943-97-3

Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens[1][2].

Methyl p-coumarate

MCE China：Methyl p-coumarate

Brand：MedChemExpress (MCE)

Cat. No.HY-N1434

CAS：3943-97-3

Synonyms：Methyl 4-hydroxycinnamate

Purity：99.80%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.

In Vitro：Methyl p-coumarate (10 μM) inhibits melanin formation in B16 mouse melanoma cells[1]. Methyl p-coumarate (200 μg/mL) shows antifungal activity against A. alternata, and inhibits Alternaria rot in jujube fruit[2]. Methyl p-coumarate (0-100 μM, 1 h) shows anti-inflammatory activity on Phorbol 12-myristate 13-acetate (HY-18739) (10 nM, 18 h)-stimulated A549 cells by suppressing the secretion of IL-6, IL-8, MCP-1, and ICAM-1[3]. Methyl p-coumarate (0-100 μM, 1 h) inhibits activation of NF-κB/AP-1 in Phorbol 12-myristate 13-acetate (HY-18739) (10 nM, 18 h)-stimulated A549 cells[3].

In Vivo：Methyl p-coumarate (5 mg/kg, p.o.) inhibits airway inflammation in Ovalbumins (HY-W250978)-induced mice with allergic asthma[3].

References：

[1]. Kubo I, et, al. Methyl p-coumarate, a melanin formation inhibitor in B16 mouse melanoma cells. Bioorg Med Chem. 2004 Oct 15;12(20):5349-54. [Content Brief]

[2]. Yuan S, et, al. Defense Responses, Induced by p-Coumaric Acid and Methyl p-Coumarate, of Jujube ( Ziziphus jujuba Mill.) Fruit against Black Spot Rot Caused by Alternaria alternate. J Agric Food Chem. 2019 Mar 13;67(10):2801-2810. [Content Brief]

[3]. Park JW, et al. Methyl P-Coumarate Ameliorates the Inflammatory Response in Activated-Airway Epithelial Cells and Mice with Allergic Asthma. Int J Mol Sci. 2022 Nov 28;23(23):14909. [Content Brief]

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MedChemExpress - Model Methyl p-coumarate -3943-97-3

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Methyl p-coumarate