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MedChemExpress - Model Glycitein -40957-83-3
MCE products for research use only. We do not sell to patients.
Glycitein
MCE China：Glycitein
Brand：MedChemExpress (MCE)
Cat. No.HY-N0016
CAS：40957-83-3
Synonyms：Glycetein
Purity：99.67%
Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Glycitein is a soy isoflavone used to study apoptosis and antioxidant.
In Vitro：Glycitein (0-30 μM, 4 days/20 h) inhibits the dextran-coated charcoal/fetal bovine serum (DDC-FBS)-induced growth (4 days) and DNA synthesis (20 h) of aortic smooth muscle cells (SMC) from stroke-prone spontaneously hypertensive rats (SHRSP)[3]. Glycitein (0-100 μM, 24 h) inhibits the viability in human gastric cancer cells, induces apoptosis and induces G0/G1 phase arrest[4]. Glycitein (100 μg/mL, 2 days) protects against Aβ-induced toxicity and oxidative stress in transgenic C. elegans[6].
In Vivo：Glycitein (3 mg/day, oral gavage, 4 days) has weak estrogenic activity, and increases uterine weight in weaning female B6D2F1 mice[1]. Glycitein (15, 30, or 45 mg/kg in diet) in sows during late pregnancy and lactation enhances antioxidative indices, decreases the content of MDA in sow's plasma and milk, improves milk composition, and enhancesthe growth performance of the sucking piglets[5].
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References：
[1]. Song TT, et al. Estrogenic activity of glycitein, a soy isoflavone. J Agric Food Chem. 1999 Apr;47(4):1607-10. [Content Brief]
[2]. Yoshida H, et al. Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells. Biosci Biotechnol Biochem. 2001 May;65(5):1211-3. [Content Brief]
[3]. Pan W, et al. Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Nutr. 2001 Apr;131(4):1154-8. [Content Brief]
[4]. Zang YQ, et al. Glycitein induces reactive oxygen species-dependent apoptosis and G0/G1 cell cycle arrest through the MAPK/STAT3/NF-κB pathway in human gastric cancer cells. Drug Dev Res. 2019 Aug;80(5):573-584. [Content Brief]
[5]. Hu YJ, et al. Effect of dietary supplementation with glycitein during late pregnancy and lactation on antioxidative indices and performance of primiparous sows. J Anim Sci. 2015 May;93(5):2246-54. [Content Brief]
[6]. Gutierrez-Zepeda A, et al. Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neurosci. 2005 Aug 25;6:54. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。