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MedChemExpress - Model 24(S)-Hydroxycholesterol -474-73-7
MCE products for research use only. We do not sell to patients.
24(S)-Hydroxycholesterol
MCE China：24(S)-Hydroxycholesterol
Brand：MedChemExpress (MCE)
Cat. No.HY-16940
CAS：474-73-7
Synonyms：24S-OHC; 24S-HC; Cerebrosterol
Purity：99.55%
Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators.
In Vitro：24(S)-Hydroxycholesterol (1, 10, 30 μM) can protect isolated rat retina from damage caused by elevated hydrostatic pressure[4].
IC50 & Target：NMDA Receptor Human Endogenous Metabolite
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References：
[1]. Yuki Kimura, et al. Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209. [Content Brief]
[2]. M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270(4):377-87. [Content Brief]
[3]. Steven M Paul, et al. The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33(44):17290-300. [Content Brief]
[4]. Ishikawa M, et al. 24(S)-Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure. Sci Rep. 2016 Sep 22;6:33886. [Content Brief]
Brand introduction:
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