MedChemExpress - Model Safranin -477-73-6

Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. It can readily intercalate into biological macromolecules, including DNA and proteins. Safranin can be used as a redox indicator in the determination of metal ion concentration[1].

Safranin

MCE China：Safranin

Brand：MedChemExpress (MCE)

Cat. No.HY-D0215

CAS：477-73-6

Synonyms：Safranine T

Storage：RT, sealed storage, away from moisture and light In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. Safranin can readily intercalate into biological macromolecules, including DNA and proteins. Safranin has antibacterial effects against gram-positive bacteria (S. aureus). Safranin can be used as a redox indicator in the determination of metal ion concentration.

In Vitro：Safranin (0.1% (w/v), 1 min) differentially stains the cell cycle of plant cells[2]. Safranin (up to 2 μM) inhibits Complex I-driven OXPHOS (in mouse brain homogenates) capacity[3]. Safranin (0.025%) shows antibacterial activity against gram-positive bacteria (S. aureus)[4].

References：

[1]. Wan H, et al. Structure characterization and optical properties investigation of the four main components of the classical phenazinium dye Safranin O. Analyst. 2019;144(24):7149-7156. [Content Brief]

[2]. Swain D, et al. Differential staining of the cell cycle of plant cells using safranin and indigo-picrocarmine. Stain Technol. 1990;65(4):197-204. [Content Brief]

[3]. Krumschnabel G, et al. Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol. 2014;542:163-81. [Content Brief]

[4]. Al-Khikani F, et al. The Antibacterial Action of Safranin and Gentian Violet. Rambam Maimonides Med J. 2022 Jul 31;13(3):e0018. [Content Brief]

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MedChemExpress - Model Safranin -477-73-6

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Safranin