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MedChemExpressModel Propylthiouracil -51-52-5

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Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research[1].
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Propylthiouracil

MCE China:Propylthiouracil

Brand:MedChemExpress (MCE)

Cat. No.HY-B0346

CAS:51-52-5

Synonyms:6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU

Purity:99.33%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research.

In Vitro:Propylthiouracil (5.5-330 μg/mL; 24 h) induces growth retardation and cytotoxicity in a dose-dependent manner in U-937 cells[2].

In Vivo:Propylthiouracil induces hypothyroidism in adult C57BL/6J and wild-derived WSB/EiJ male mice by given an iodine-deficient diet supplemented with 0.15% Propylthiouracil[1].

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References:

[1]. Lamis Chamas, et al. A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. Int J Mol Sci. 2022 Oct 8;23(19):11938.  [Content Brief]

[2]. Utsana Puapermpoonsiri, et al. Synergistic effect of phospholipid-based liposomes and propylthiouracil on U-937 cell growth. J Liposome Res. 2005;15(3-4):215-27.  [Content Brief]

Brand introduction:
•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
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•   The biological activity of the products has been verified by the experiments of customers in various countries;
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