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MedChemExpress - Model Broxyquinoline -521-74-4
MCE products for research use only. We do not sell to patients.
Broxyquinoline
MCE China：Broxyquinoline
Brand：MedChemExpress (MCE)
Cat. No.HY-B1212
CAS：521-74-4
Synonyms：Dibromohydroxyquinoline; 5,7-Dibromo-8-hydroxyquinoline
Purity：99.89%
Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Broxyquinoline (Dibromohydroxyquinoline) is an effective inhibitor of severe fever with thrombocytopenia syndrome virus (SFTSV) with an IC50 of 5.8 µM. Additionally, Broxyquinoline is an inhibitor of CpACBP1 with an IC50 of 64.9 μM. CpACBP1 is a fatty acyl-CoA binding protein of Cryptosporidium parvum, thus Broxyquinoline has the potential to inhibit parasite growth. Broxyquinoline shows promise for research in the field of infectious diseases.
In Vitro：Broxyquinoline (1 mM, 10 μM, 44 h) has almost no active effect on Human ileocaecal colorectal adenocarcinoma (HCT-8) cells[1]. Broxyquinoline (0-1.0 mM, 44 h) exhibits antiparasitic activity in vitro[1]. Broxyquinoline (10 μM, 72 h) does not show significant toxicity to Vero cells and exhibits activity against severe fever with thrombocytopenia syndrome virus (SFTSV) [2].
In Vivo：A 5:1 mixture of broxyquinoline and broxaldin (0.1 g/kg, p.o., once daily for 32 days) did not cause any histological changes in the visceral organs of rats[3].
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References：
[1]. Shuofeng Yuan, et al. Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus. Viruses. 2019 Apr 25;11(4):385. [Content Brief]
[2]. Fritzler JM, et al. Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP). J Antimicrob Chemother. 2012 Mar;67(3):609-17. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。