MedChemExpress - Model Lumisterol 3 (>90%) -5226-01-7

Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D[1].

Lumisterol 3 (>90%)

MCE China：Lumisterol 3 (>90%)

Brand：MedChemExpress (MCE)

Cat. No.HY-112023

CAS：5226-01-7

Synonyms：9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C

Purity：97.77%

Storage：-80°C, protect from light, stored under nitrogen *The compound is unstable in solutions, freshly prepared is recommended.

Shipping：Shipping with dry ice.

Description：Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D.

In Vitro：Lumisterol 3 (L3) (1-100 nM, 24 h) significantly reduces UVB-induced cellular oxidant formation in a dose-dependent manner and inhibits the proliferation of UVB-irradiated keratinocytes[2]. Lumisterol 3 (L3) (100 nM, 24 h) promotes repair of cellular DNA damage induced by UVB irradiation and increases the nuclear/cytosolic Nrf2 ratio and nuclear p53 expression level in UVB-irradiated cells[2]. Lumisterol 3 (L3) (100 nM, 3 h) significantly enhances the expression levels of Nrf2-regulated antioxidant proteins, including catalase and HO-1 in UVB-irradiated cells[2].

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Slominski AT, Li W, Kim TK, et al. Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol. 2015;151:25-37. [Content Brief]

[2]. Anyamanee Chaiprasongsuk, et al. Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms. Redox Biol. 2019 Jun;24:101206. [Content Brief]

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MedChemExpress - Model Lumisterol 3 (>90%) -5226-01-7

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Lumisterol 3 (>90%)