MedChemExpress - Model N-Bis(2-hydroxypropyl)nitrosamine -53609-64-6

N-Bis(2-hydroxypropyl)nitrosamine is a tumor model inducing agent and a metabolite of di-n-propylnitrosamine (DPN). N-Bis(2-hydroxypropyl)nitrosamine can be used to construct pancreatic cancer[1][2].

N-Bis(2-hydroxypropyl)nitrosamine

MCE China：N-Bis(2-hydroxypropyl)nitrosamine

Brand：MedChemExpress (MCE)

Cat. No.HY-112085

CAS：53609-64-6

Synonyms：Di(2-hydroxypropyl)nitrosamine; Diisopropanolnitrosamine

Purity：98.0%

Storage：Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：N-Bis(2-hydroxypropyl)nitrosamine is a tumor model inducing agent and a metabolite of di-n-propylnitrosamine (DPN). N-Bis(2-hydroxypropyl)nitrosamine can be used to construct pancreatic cancer.

In Vitro：N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity[1].

In Vivo：N-Bis(2-hydroxypropyl)nitrosamine causes the tumors to develop in the lung, liver, and thyroid of rats at a dose of 100 ppm, in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats at a dose of 500 ppm, and in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats at both doses[1]. Bisphenol A (BPA) enhances the susceptibility to thyroid carcinoma stimulated by N-Bis(2-hydroxypropyl)nitrosamine (DHPN; 2800 mg/kg) in rats[2].

References：

[1]. Pour P, et al. Effect of beta-oxidized nitrosamines on syrian hamsters. III. 2,2'-Dihydroxydi-n-propylnitrosamine. J Natl Cancer Inst. 1975 Jan;54(1):141-6. [Content Brief]

[2]. Pour P, et al. Cancer of the pancreas induced in the Syrian golden hamster. Am J Pathol. 1974 Aug;76(2):349-58. [Content Brief]

[3]. Konishi Y, et al. Effect of dose on the carcinogenic activity of orally administered N-bis(2-hydroxypropyl)nitrosamine in rats. Gan. 1978 Aug;69(4):573-7. [Content Brief]

[4]. Zhang J, et al. Low dose of Bisphenol A enhance the susceptibility of thyroid carcinoma stimulated by DHPN and iodine excess in F344 rats. Oncotarget. 2017 Jul 22;8(41):69874-69887. [Content Brief]

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MedChemExpress - Model N-Bis(2-hydroxypropyl)nitrosamine -53609-64-6

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N-Bis(2-hydroxypropyl)nitrosamine