MedChemExpress - Model Pentagastrin -5534-95-2
MCE products for research use only. We do not sell to patients.
Pentagastrin
MCE China：Pentagastrin
Brand：MedChemExpress (MCE)
Cat. No.HY-A0261
CAS：5534-95-2
Synonyms：ICI-50123
Purity：99.08%
Storage：Sealed storage, away from moisture and light Powder -80°C 2 years -20°C 1 year *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCKB) receptor antagonists with IC50 values of 11 nM and 1100 nM for CCKB and CCKA, respectively. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury..
In Vitro：Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold[1].?Pentagastrin (ICI-50123) (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells[1].
In Vivo：Pentagastrin (ICI-50123) (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury[2].
IC50 & Target：CCKBR
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References：
[1]. Smith AJ, et al. Characterisation of CCKB receptors on GH3 pituitary cells: receptor activation is linked to Ca2+ mobilisation. Eur J Pharmacol. 1994 Apr 15;267(2):215-23. [Content Brief]
[2]. Tanaka S, et al. Pentagastrin gastroprotection against acid is related to H2 receptor activation but not acid secretion. Gut. 1998 Sep;43(3):334-41. [Content Brief]
Brand introduction:
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