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MedChemExpressModel (Rac)-Idroxioleic acid -56472-29-8

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(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect[1].
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(Rac)-Idroxioleic acid

MCE China:(Rac)-Idroxioleic acid

Brand:MedChemExpress (MCE)

Cat. No.HY-129467

CAS:56472-29-8

Synonyms:2-Hydroxyoleic acid; 2-OHOA; LAM561

Purity:98.0%

Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect.

In Vitro:(Rac)-Idroxioleic acid (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1]. (Rac)-Idroxioleic acid (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].

In Vivo:(Rac)-Idroxioleic acid markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1].

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References:

[1]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.  [Content Brief]

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