MedChemExpress - Model Palmitic acid -57-10-3
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Palmitic acid
MCE China：Palmitic acid
Brand：MedChemExpress (MCE)
Cat. No.HY-N0830
CAS：57-10-3
Purity：99.76%
Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.
In Vitro：Palmitic acid (0.1, 0.25 or 0.5 mM; 12-72 h) increases the mRNA levels of Notch1, −2 and −4 in LX2, Huh7 and MIHA hepatic cell lines[2].
IC50 & Target：Microbial Metabolite Human Endogenous Metabolite
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References：
[1]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90. [Content Brief]
[2]. Wen-Jin Ding, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708. [Content Brief]
[3]. Liaqat H, et al. Antioxidant Effect of Wheat Germ Extracts and Their Antilipidemic Effect in Palmitic Acid-Induced Steatosis in HepG2 and 3T3-L1 Cells. Foods. 2021 May 12;10(5):1061. [Content Brief]
[4]. Jiang H, et al. Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Atherosclerosis. 2010 May;210(1):71-7. [Content Brief]
[5]. Ding WJ, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708. [Content Brief]
[6]. Urso CJ, et al. Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids. Int J Mol Sci. 2021 Aug 23;22(16):9093. [Content Brief]
[7]. Wu D, et al. Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α. Int J Mol Med. 2014 Dec;34(6):1706-12. [Content Brief]
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