MedChemExpress - Model Uridine 5'-monophosphate -58-97-9

Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea[1][2][3].

Uridine 5'-monophosphate

MCE China：Uridine 5'-monophosphate

Brand：MedChemExpress (MCE)

Cat. No.HY-101981

CAS：58-97-9

Synonyms：5'-Uridylic acid

Purity：99.98%

Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.

In Vitro：Uridine 5'-monophosphate (10 mM, 6 h) promotes late apoptosis in pig intestinal epithelial cells IPEC-J2[1].

In Vivo：Uridine 5'-monophosphate (476 mg, oral, daily, 10 days) promotes apoptosis and renewal of intestinal villus tip epithelial cells in pigs, which benefits gut development and reduces the rate of diarrhea[1]. Uridine 5'-monophosphate (0.02-1 mmol/kg, i.g., single dose) can enhance the synthesis of CDP-choline in the brains of gerbils[2]. Uridine 5'-monophosphate (30 mg/kg, i.v., single dose) has protective properties for the heart in rats, preventing ischemic injury and some arrhythmias[3].

IC50 & Target：Human Endogenous Metabolite Microbial Metabolite

References：

[1]. Li G, et al. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food Funct. 2019 Jul 17;10(7):4081-4089. [Content Brief]

[2]. Mehmet Cansev, et al. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058(1-2):101-8. [Content Brief]

[3]. Irina B Krylova, et al. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Exp Gerontol. 2006 Jul;41(7):697-703. [Content Brief]

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MedChemExpress - Model Uridine 5'-monophosphate -58-97-9

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Uridine 5'-monophosphate