MedChemExpress - Model Uracil -66-22-8

Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins[1][2][3][4][5].

Uracil

MCE China：Uracil

Brand：MedChemExpress (MCE)

Cat. No.HY-I0960

CAS：66-22-8

Purity：99.94%

Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins.

In Vitro：Uracil (2500μM) mainly phosphorylates 5-FU (2.5-250 μM) with slightly degradation in Yoshida sarcoma cells, whereas in liver slices, degradation of 5- FU is greater than its phosphorylation[4].

IC50 & Target：Human Endogenous Metabolite

References：

[1]. Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611. [Content Brief]

[2]. Viswanathan A, et al. Phenotypic change caused by transcriptional bypass of uracil in nondividing cells. Science. 1999 Apr 2;284(5411):159-62. [Content Brief]

[3]. Visnes T, et al. Uracil in DNA and its processing by different DNA glycosylases. Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):563-8. [Content Brief]

[4]. Ikenaka K, et al. Effect of uracil on metabolism of 5-fluorouracil in vitro. Gan. 1979 Jun;70(3):353-9. [Content Brief]

[5]. de Koning HP, et al. A highly selective, high-affinity transporter for uracil in Trypanosoma brucei brucei: evidence for proton-dependent transport. Biochem Cell Biol. 1998;76(5):853-8. [Content Brief]

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MedChemExpress - Model Uracil -66-22-8

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Uracil