MedChemExpress - Model Dimethyl sulfone -67-71-0

Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective[1][2][3].

Dimethyl sulfone

MCE China：Dimethyl sulfone

Brand：MedChemExpress (MCE)

Cat. No.HY-Y1314

CAS：67-71-0

Purity：99.60%

Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective.

In Vitro：Dimethyl sulfone (25 mM/mL for 15.5 μL/mL; 24 h) inhibits the proliferation of cultured bovine choriocapillary endothelial (CCE) cells[2].

In Vivo：Dimethyl sulfone (for 0, 0.01, 0.03, 0.1, 0.3 and 1.0 mL; i.p.; single dose) shows neuroprotective effect with significant infarction volume reduction in ischemia rats[3].

IC50 & Target：Microbial Metabolite Human Endogenous Metabolite

References：

[1]. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Dimethyl Sulfone. 2022 Mar 21. [Content Brief]

[2]. Eter N, et al. DMSO mimics inhibitory effect of thalidomide on choriocapillary endothelial cell proliferation in culture. Br J Ophthalmol. 2002 Nov;86(11):1303-5. [Content Brief]

[3]. Shimizu S, et al. Dimethylsulfoxide (DMSO) treatment reduces infarction volume after permanent focal cerebral ischemia in rats. Neurosci Lett. 1997 Dec 19;239(2-3):125-7. [Content Brief]

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MedChemExpress - Model Dimethyl sulfone -67-71-0

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Dimethyl sulfone