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MedChemExpressModel L-Asparagine -70-47-3

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L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity[1][2][3].
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L-Asparagine

MCE China:L-Asparagine

Brand:MedChemExpress (MCE)

Cat. No.HY-N0667

CAS:70-47-3

Synonyms:(-)-Asparagine; Asn; Asparamide

Purity:98.0%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping:Room temperature in continental US; may vary elsewhere.

Description:L-Asparagine ((-)-Asparagine) is a non-essential amino acid involved in the metabolic control of nerve and brain tissue cell function. L-Asparagine has antitumor activity.

In Vitro:L-Asparagine (0.03 mM) can reverse the proliferation decline of six human cancer cells induced by ASNS siRNA knockdown[2]. L-Asparagine (10 mM, 4 h) can stimulate ODC activity and proliferation in IPEC-J2 cells[3].

IC50 & Target:Microbial Metabolite Human Endogenous Metabolite

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References:

[1]. Chiu M, et al. Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia. Front Oncol. 2020 Jan 9;9:1480.  [Content Brief]

[2]. Pathria G,et al. Translational reprogramming marks adaptation to asparagine restriction in cancer. Nat Cell Biol. 2019 Dec;21(12):1590-1603.  [Content Brief]

[3]. Kandil HM, et al. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. Am J Physiol. 1995 Oct;269(4 Pt 1):G591-9.  [Content Brief]

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•   MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
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•   Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
•   It has a professional experimental center and strict quality control and verification system;
•   Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
•   The biological activity of the products has been verified by the experiments of customers in various countries;
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•   Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
•   It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。