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L-Arginine butanoate

MCE China：L-Arginine butanoate

Brand：MedChemExpress (MCE)

Cat. No.HY-N0455D

CAS：80407-72-3

Synonyms：(S)-(+)-Arginine butanoate

Purity：98.0%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping：Room temperature in continental US; may vary elsewhere.

Description：L-Arginine butanoate ((S)-(+)-Arginine butanoate) is a compound consisting of L-Arginine and butanoate. L-Arginine is one of the essential nutrients in the human body and participates in various biochemical processes. Butanoate is a short-chain fatty acid commonly used as a food additive and solvent in pharmaceutical formulations.

In Vivo：.f12{ font-size: 12px; } .fwb{ font-weight: bold; } .lh22{ line-height: 22px;; } .lh23 { line-height: 23px; } .pl13{ padding-left: 13px;; } .part { margin-top: 18px; } .mold-first-tit { width: 100%; height: 44px; line-height: 44px; background: #F9F7FB; border-bottom: 1px solid #EBE4F6; padding-left: 16px; box-sizing: border-box; margin-bottom: 17px; } .mold-second-tit:before { content:; width: 6px; height: 6px; display: inline-block; border-radius: 50%; background: rgba(255,102,0,0.4); margin-right: 12px; position: relative; top: -3px; } .lft-border { border-left: 1px dotted #EBE4F6; padding-right: 12px; margin-left: 3px; box-sizing: border-box; padding-bottom: 12px; } /* .part .dec:last-child { border-bottom: 0; } */ .dec { margin: 10px 15px 0; padding-bottom: 10px; border-bottom: 1px dashed #EBE4F6; } .btm-border { border-left: 1px dashed #EBE4F6; } .text-bg { margin-top: 10px; background: #FFFBF1; padding: 14px; border-bottom: 0; position: relative; } .text-note-bg { margin-top: 10px; background: #FFFDF7; padding: 12px; border-bottom: 0; position: relative; } .text-note { width: 51px; height: 20px; line-height: 20px; background: #FFE2AA; text-align: center; border-radius: 0 0 8px 0; position: absolute; top: 0; left: 0; } .text-note-dec { margin-top: 15px;; } Induction of experimental acute pancreatitis[4][5] Background L-Arginine is a substrate for endothelial nitric oxide synthase (eNOS) to produce NO, which can be metabolized into nitric oxide (NO), polyamines or L-proline, stimulating inflammatory responses. L-Arginine can also selectively destroy pancreatic acinar cells, leading to acute necrotizing pancreatitis. Specific Mmodeling Methods Rat[4]: male • Wistar albino rats • 150 gAdministration: 250 mg, 500 mg, 750 mg every 100 g body weight (L-Arginine for example; HY-N0455) • ip for single dose • starved for 15 hoursMice[5]: male • ICT mouse • 4-week-old • 25-30 gAdministration: total 450 mg/100 g body weight • ip for 2 doses, with 1 hr interval • sacrificed at 72 hours Note 1. 当剂量超过 500 mg/100 g 体重时，将导致大部分大鼠在注射后数小时内死亡；当接受剂量低于 250 mg 时，诱导出现的胰腺病的症状会较轻[4]。2. 文献中溶解方法参考[5]：将 L-Arginine 粉末溶解于 0.9% 生理盐水中，用 5 N 盐酸调节 pH 至 7，制得 L-Arginine 溶液。 Modeling Record Appearance changes: weight loss, lower activity, softer hairTissue morphology: pancreatic edema, damage, atrophy, granulation tissue contraction and chalky spots (location of fat necrosis). Cellular changes: basophils decrease and vesicles, cell pyknosis, nuclear fragmentation. Pancreatic albino cells disappear and die, and pancreatic tissue is replaced by monocytes and fibroblasts. Molecular changes: serum amylase levels increase, and fat necrosis is obvious. Correlated Product(s): Curcumin (HY-N0005)

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