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Riboflavin

MCE China：Riboflavin

Brand：MedChemExpress (MCE)

Cat. No.HY-B0456

CAS：83-88-5

Synonyms：Vitamin B2; E101

Purity：99.89%

Storage：4°C, protect from light *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction.

In Vitro：Riboflavin (5-50 µM, 24 h) has a strong cytotoxic effect on HL60 cells after UV irradiation that is mediated by apoptosis[2]. Riboflavin (0.76-48.76 nM, 96 h) increases cell viability and glutathione reductase activity and reduces apoptosis of HepG2 cells in a dose-dependent manner[3].

In Vivo：Riboflavin (10 mg/kg, p.o., daily) promotes the growth of swiss albino mice[4]. Riboflavin (1-600 mg/kg, p.o., one time) produces antinociceptive, antihyperalgesic, and anti-inflammatory effect in formalin, carrageenan-induced thermal hyperalgesia, and spinal nerve ligation rat models[5]. Riboflavin (3-100 mg/kg, i.p., one time) inhibits the nociceptive response in a dose-dependent manner in mice model of acetic acid-induced constriction[6]. Riboflavin (6-12 mg/kg, i.p., one time) decreases the second phase nociceptive response in mice model of formaldehyde-induced[6].

IC50 & Target：Human Endogenous Metabolite Microbial Metabolite

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References：

[1]. Thakur K, et al. Riboflavin and health: A review of recent human research. Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660.  [Content Brief]

[2]. de Souza AC, et al. A promising action of riboflavin as a mediator of leukaemia cell death. Apoptosis. 2006 Oct;11(10):1761-71.  [Content Brief]

[3]. Xin Z, et al. Riboflavin deficiency induces a significant change in proteomic profiles in HepG2 cells. Sci Rep. 2017 Apr 3;7:45861.  [Content Brief]

[4]. Agte VV, et al. Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice. Biol Trace Elem Res. 1998 Nov;65(2):109-15.  [Content Brief]

[5]. Granados-Soto V, et al. Riboflavin reduces hyperalgesia and inflammation but not tactile allodynia in the rat. Eur J Pharmacol. 2004 May 10;492(1):35-40.  [Content Brief]

[6]. França DS, et al. B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. Eur J Pharmacol. 2001 Jun 15;421(3):157-64.  [Content Brief]