MedChemExpress - Model Mogroside V -88901-36-4

Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research[1][3].

Mogroside V

MCE China：Mogroside V

Brand：MedChemExpress (MCE)

Cat. No.HY-N0502

CAS：88901-36-4

Purity：99.01%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research.

In Vitro：Mogroside V (20 μM, 40 h) reducs the ROS levels in in vitro maturation (IVM) oocytes[1]. Mogroside V (20 μM, 40 h) can enhance mitochondrial function in oocytes[1]. Mogroside V (1-250 μM, 24 h) promots apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells) and may be mediated through regulating the STAT3 signaling pathway[3].

In Vivo：Mogroside V (100 mg/kg for Oral administration) transforms to 26 metabolites by the process of dehydrogenation, deoxidation, oxidation and isomerization in type 2 diabetes (T2D) model rats[1].

References：

[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.

[2]. Nie J, et al. Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development. Theriogenology. 2020 Jan 1;141:35-40. [Content Brief]

[3]. Zhou G, et al. The metabolism of a natural product mogroside V, in healthy and type 2 diabetic rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 15;1079:25-33. [Content Brief]

[4]. Liu C, et al. A natural food sweetener with anti-pancreatic cancer properties. Oncogenesis. 2016 Apr 11;5(4):e217. [Content Brief]

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MedChemExpress - Model Mogroside V -88901-36-4

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Mogroside V