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MedChemExpressModel Pyruvate carboxylase -9014-19-1

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Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3− and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells[1][2].
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Pyruvate carboxylase

MCE China:Pyruvate carboxylase

Brand:MedChemExpress (MCE)

Cat. No.HY-P2989

CAS:9014-19-1

Storage:Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Pyruvate carboxylase is a biotin-containing enzyme that catalyzes the HCO3− and MgATP dependent carboxylation of pyruvate to form oxaloacetate. Pyruvate carboxylase plays an essential role in controlling whole-body energetics through regulation of gluconeogenesis in the liver, synthesis of fatty acids in adipocytes, and insulin secretion in pancreatic β cells.

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References:

[1]. Jitrapakdee S, et al. Structure, mechanism and regulation of pyruvate carboxylase. Biochem J. 2008 Aug 1;413(3):369-87.

[2]. Kiesel VA, et al. Pyruvate carboxylase and cancer progression. Cancer Metab. 2021 Apr 30;9(1):20.  [Content Brief]

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