MedChemExpress - Model Propylparaben -94-13-3

Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats[1][2][3][4][5][6].

Propylparaben

MCE China：Propylparaben

Brand：MedChemExpress (MCE)

Cat. No.HY-N2026

CAS：94-13-3

Synonyms：Propyl parahydroxybenzoate; Propyl 4-hydroxybenzoate

Purity：99.74%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats.

In Vitro：Propylparaben protects isolated adult rat cardiomyocytes from ischemia-reperfusion injury. Propylparaben (500 μM; 10 min) significantly reduces cell death induced by 45 minutes of sustained ischemia and 15 hours of reperfusion[4].Propylparaben (250 μM, 500 μM) reversibly blocks voltage-gated sodium channels in a concentration- and voltage-dependent manner[4].Propylparaben (0-1 μM; 48 h) reduces basal lipolysis of mature 3T3-L1 white fat cells, such as insulin-stimulated glucose uptake. But does not change the base 2-NBDG uptake[5].

In Vivo：Propylparaben (7.5 mg/kg/day; po; 8 months) treats female mice and significantly alters the estrus cycle, hormone levels, and ovarian reserve, accelerating ovarian aging in adult mice. Studies have demonstrated that melatonin supplementation can prevent proylparaben induced granulosa cell steroid production dysfunction[6].

References：

[1]. S Oishi, et al. Effects of propyl paraben on the male reproductive system. Food Chem Toxicol. 2002 Dec;40(12):1807-13. [Content Brief]

[2]. Gal A, et, al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019 Oct;89:100-106. [Content Brief]

[3]. Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27 Suppl 4:1-82. [Content Brief]

[4]. Ji X, et al. Propyl paraben inhibits voltage-dependent sodium channels and protects cardiomyocytes from ischemia-reperfusion injury. Life Sci. 2004 Apr 30;74(24):3043-52. [Content Brief]

[5]. Yan W, et al. Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice. Ecotoxicol Environ Saf. 2022 Apr 15;235:113432. [Content Brief]

[6]. Gal A, et al. Propylparaben inhibits mouse cultured antral follicle growth, alters steroidogenesis, and upregulates levels of cell-cycle and apoptosis regulators. Reprod Toxicol. 2019 Oct;89:100-106. [Content Brief]

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MedChemExpress - Model Propylparaben -94-13-3

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Propylparaben