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ChroMem - Model GMP -Membrane Separation Unit
ChroMem units are similar to the PiloMem systems but GMP compliant, ATEX certified for use in Ex Zone II and suitable for operation with pure organic solvents and for the pressure-driven membrane processes microfiltration, ultrafiltration, nanofiltration and reverse osmosis up to 40 bar. Typically they are equipped with nanofiltration membranes and used e.g. in combination with preparative chromatography, for concentration and/or solvent change. There are two standard system sizes, the smaller ChroMem I and the larger ChroMem II.
The membrane modules are interchangeable. We offer the suitable modules for ceramic membranes and polymeric spiral-wound membranes, which we have optimized especially for minimal dead volume.
The design of the systems is particularly focused on: Easy emptying, good cleanability (CIP) and low minimum working volume with the largest possible membrane area.
Concentration and diafiltration can be automated. All measurement equipment also for this operation is integrated in the unit therefore no external signals are needed. The units are temperature contolled and pump speeds are electronically controlled.
Some details:
- product contacting metal parts stainless steel 316L or equivalent, surfaces Ra 0.8 if required
- electronically controlled pump speeds
- electronic pressure indicators with high precision 0.1% for measurement of feed pressure and feed side pressure drop
- precise Corriolis mass flow meters
- integrated heat exchanger and temperature control
- safety shut-off: overtemperature, overpressure, low pressure (dry running protection)
- stainless steel control cabinet, polished grain size 320, with electronic display of feed pressure, retentate pressure, temperature, membrane cross flow, feed pump flow, permeate flow and all operating switches and controlls, optionaly SPS controlled
- no screwed tube connections, no dead zones
- pump head of high pressure pump modified to dead zone free sealing
- orbital welding for product contacting areas where possible, otherwise inside ground welding
Documentation:
- P&I scheme
- wiring diagram
- instrument list with specifications
- data sheets for components
- calibration protocolls for measurement instruments
- complete manufacturing documentation (welder certificates, material certificates, isometrie, orbital welding parameters)
- declaration of EG conformity (includes ATEX)
- material certificates EN10204 3.1 for product contacting metal parts,
- FDA-certificates for seals and flexible tubes
- pump grease USDA-H1 conformity
- operation manual
- list of spare parts
- FAT protocoll
- IQ/OQ at customers site
