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NewomicsModel UniESI -Single Ion Source

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Using a single ion source interfaced with mass spectrometers, you can achieve ultrasensitive single-cell proteomics, and reproducible high-throughput quantitation of proteins or small molecules. The UniESI Source is a game-changing product. A truly open-source end-to-end solution that puts an end to juggling 3-4 ion sources with different tubing connections on the same mass spectrometer.

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Built for Superior Microflow and Nanoflow LC-MS

Sensitivity
5 - 50x
more sensitive compared to conventional methods.

Robustness
CV ≤ 5%
from 300 plasma injections.

Throughput
< 1 min.
per sample for direct infusion ESI. More than 60 samples per hour.

  • The first ion source with multiple swappable microflow and nanoflow modules
  • Compatible with all mass spectrometers from Thermo, Bruker, Agilent, Shimadzu, and Waters
  • Plug-and-play platform for Newomics M3 emitters and MEA chips
  • Plug-and-play platform for third-party columns and other LCMS consumables
  • A universal, unified ion source for low-flow electrospray ionization mass spectrometry
  • Ionization Mode : Atmospheric pressure electrospray ionization (ESI), both positive and negative mode.
  • ESI Probe : Newomics M3 Emitter and MEA Chip (refer to M3 Emitter and MEA Chip specification)
  • Open or Closed System : Semi-closed source
  • Flow Rate :
  • Nano (20 – 1000 nL/min), for nanoMEA chips
  • Micro (1 – 50 µL/min), for M3 emitters and microMEA chips
  • Spray Angle :
  • Fixed angle of 25° for M3 emitters
  • 0° angle for nanoMEA chips
  • Capillary Voltage : 0 – 6 kV
  • Spray Current : 0 – 10 µA, max. 50µA
  • Sheath Gas Flow Setting : 0 – 30 (arbitrary units)
  • Auxiliary Gas Flow Setting : 0 – 20 (arbitrary units, optional)
  • Translational Stage : Linear XY-axis manual stage, ±5 mm travel distance, 30 µm travel accuracy
  • Camera : 1.3M pixels, 20x - 90x magnification rate, color CMOS sensor, up to 30 fps frame rate
  • Light Source : Cool white (9000K) 5 mm round LED light, luminous intensity 46400 mcd
  • Connection :
  • Face seal, finger-tight 10-32 threaded fittings including Thermo nanoViper, IDEX MarvelX and MarvelXACT, Waters ZenFit, Phenomenex SecurityLink, VICI Cheminert C360IZR1, and nanoConnect
  • Unit Dimension :
    • Width: 25 cm (9.8 in.)
    • Height: 17.5 cm (6.9 in.)
    • Depth: 15 cm (5.9 in.)
    • Unit Weight : 3 kg (6.6 lbs)