Solubility, Permeability, Dissolution, and Human Absorption

Avoid solubility surprises with real-time concentration measurement

Follow your API concentration in real time using in situ UV dip probes. No filtering required, as spectral processing tools ensure turbidity does not interfere with analysis. Concentration measurements collected as fast as every 5 seconds without perturbing the system. Follow polymorph changes, excipient effects and measure solubility in small volumes. The API-Sparing and small volume design economizes for many test media, including simulated and real intestinal and gastric fluids to be examined. Up to 8 samples measured simultaneously.

Maximize solubility throughput with a fully automated liquid handling system

Conduct high quality thermodynamic pH-solubility measurements with our patented miniaturized shake flask procedure. Screen samples or excipient and investigate   SAR* in a 96-well microtitre plate format.  The integrated software features peak shape analysis to flag impurities or decomposition. µSOL Evolution is available on two robotic platforms: TECAN Evo® and Beckman Biomek-FX® ADMETox Workstation   *SAR = Structure Activity Relationships

Our entry level permeability system features manual liquid handling

The µSOL Explorer package combines the protocols, consumables and software necessary for solubility analysis with a yearly or perpetual subscription. Your lab will be up and running the solubility assay with pION’s detailed explanations, technical protocols and test  compounds for verification of the method. Additionally, you can rely on technical support from out researchers.

Maximize permeability throughput with a fully automated liquid handling system

Using our patented Double-Sink™ PAMPA method coupled with the Gut-Box™ for modeling oral absorption at the discovery phase, Caco-2 testing can be postponed. Later on, the Caco-2 can then focus on transport mechanisms. PAMPA models include the GIT (gastrointestinal tract), BBB (blood-brain barrier), and skin penetration. The PAMPA  Evolution is available on high-throughput, high accuracy liquid handling systems: TECAN Evo® and Beckman Biomek-FX® ADMETox Workstation.

Our entry level permeability system features manual liquid handling

The PAMPA Explorer package combines the protocols, consumables and software necessary for permeability analysis with a yearly or perpetual subscription. Your lab will be up and running the PAMPA assay with pION’s detailed explanations, technical protocols and test compounds for verification of the method. Additionally, technical support from our researchers are ready to answer any questions.

UV fiber optic, in-situ detection system for the QC in manufacturing

The Rainbow employs a patented process for real-time data acquisition and dynamic presentation of results. UV in-situ fiber optic detection provides accurate dissolution measurements without the high cost, extensive maintenance, operator involvement and slow turnaround time of conventional methods. Change the data acquisition rate as the dissolution proceeds to collect data for both rapid-release and extended release solid dosage forms. IndigoSAM™ software provides security tools commonly required for 21 CFR Part 11 and  GMP compliance.

API-sparing dissolution research for early development laboratories

Characterize intrinsic dissolution in early development when the active pharmaceutical ingredient is not available in large quantities. Reduce API consumption by 10,000 fold. The µDISS Profiler can 1) measure intrinsic dissolution; 2) detect polymorphic changes; 3) follow stability profiles; 4) determine equilibrium solubility. The low volume apparatus requires sub-milligram quantities of API.  The modeling algorithm calculates intrinsic dissolution rate directly from powdered samples. Researchers can also screen excipients and formulations using buffers including FaSSIF and FeSSIF media. Up to 8 samples measured simultaneously

Intrinsic dissolution rates that correlate with Wood’s apparatus measurements

Measure dissolution rates earlier, with 100 times less API than required for the conventional Wood’s apparatus.  The Mini-IDR produces 5 mg rotating disks for intrinsic dissolution rate (IDR) measurements.  The compression system produces disks having a uniform, flat surface; the die is then placed into a holder with a Teflon® coated magnetic stirrer. The stirrer-die assembly is placed in a 25 mL glass vial ready for analysis using the μDISS Profiler.