Interherence - Model QuScite -Waveguide-based Total Internal Reflection Microscopy System

QuScite introduces an innovative waveguide-based total internal reflection microscopy system, setting a new standard for fluorescence and dark-field measurements. This system enhances imaging capabilities by providing pure TIRF illumination without epi-fluorescence contamination, and it allows the capture of TIRF images over a considerable area of 16 mm². Designed for compatibility with various imaging systems, it achieves a superior signal-to-noise ratio, increasing contrast and resolution by decoupling excitation from the detection pathway. This approach improves localization precision, reduces phototoxicity and bleaching rates, and enables efficient use in live cell imaging or single-molecule assays. QuScite is a user-friendly, plug-and-play solution that integrates seamlessly into multiple microscope configurations, requiring no manual alignment. Utilizing proprietary waveguide technology to create an evanescent field, QuScite accommodates a broad range of scientific applications with its automated light source integration, exceptional field homogeneity, and scalability across different objective configurations.