AAV Services
Wyatt Technology provides the instruments and methods you need for quantifying multiple critical quality attributes of AAV-based therapies throughout the product life cycle. Our solutions are simple to learn and operate, yet directly access the core biophysical properties that define these CQAs.
The following techniques are rapid, fully automated and require little hands-on effort:
- Size-exclusion chromatography with multi-angle light scattering (SEC-MALS)
- High-throughput dynamic light scattering (HT-DLS) and
- Field-flow fractionation with MALS (FFF-MALS)
To learn how light scattering technologies can enhance your AAV characterization workflow, request the brochure Solutions for AAV Characterization.
SEC-MALS is a powerful analytical technique that provides many benefits:
- Quantify capsid concentration, Vg/Cp and aggregate content
- Multiple CQAs in a single automated run
- No primers or reagents
- Unmatched accuracy, precision and repeatability
- Appropriate for product development, formulation and process development
- GMP-compliant for quality control and lot release
AAV Method Implementation and Training Service
Wyatt has developed a personalized, on-site, application-specific training to bring customers up to speed in a matter of days. AAV MI&T saves significant time and effort in learning, method development and validation.
SOP Guidance Manual: Critical quality attributes of AAVs by SEC-MALS
This comprehensive document serves as a complete reference and pathway to customizing, qualifying and implementing the SEC-MALS AAV method for your specific needs. Use this manual to prepare it for adoption as a platform method for all AAV development and production.
Please contact us for additional details on our solutions for implementing SEC-MALS characterization of AAVs.