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Drug Target Product Applications
13 applications found
Explore interaction profiles and identify off-target binding. Most drugs in common use are small organic molecules which interact functionally with proteins, either acting as ligands for receptors, inhibiting enzymes or blocking protein interactions, etc. ...
ByCambridge Protein Arrays Ltd. (CPAP) based in Cambridge, UNITED KINGDOM
This purification-free method aids in producing significant insights into protein behavior, proving invaluable for drug development targeting membrane ...
ByFluidic Sciences Ltd based in Hertfordshire, UNITED KINGDOM
The application of DNA-based therapy mainly includes DNA-encoded compound library for new drugs research, genetically engineered bacterias drugs, nuelic acid vaccines, recombinant antibodies, small nucleic acid drugs, and gene editing. Firstly, we can quickly promote the development of new drugs through the construction of DNA coding libraries. Secondly, we can realize the mass production of protein drugs, antibiotic ...
ByCD Biosciences - htDNA-chip® based in Shirley, NEW YORK (USA)
In many therapeutic areas, current treatments involve significant side effects. Combining drug compounds with affinity agents that target specific cell surface receptors can dramatically reduce off-target effects and improve treatment effectiveness. In several studies, aptamer-mediated drug delivery has reduced toxicity and improved drug performance. ...
ByBase Pair Biotechnologies, Inc. based in Pearland, TEXAS (USA)
The immune response that occurs when an organ or tissue is transplanted (grafted) from one individual to another is referred to as a graft versus host response. This presents a major problem following transplantation as the immune system of the recipient sees the grafted tissue as foreign and proceeds to attack ...
ByEnpicom B.V. based in s-Hertogenbosch, NETHERLANDS
Functional ultrasound (fUS) imaging is emerging as a powerful tool in neuropharmacology to study the effects of drugs on brain activity. Unlike fMRI, fUS offers increased sensitivity and compatibility with awake animal models, providing an unbiased view of drug interactions with neural substrates. Recent studies by Theranexus have utilized fUS to observe the hemodynamic response to different pharmacological interventions, such as the combination of donepezil and mefloquine, which ...
ByIconeus based in Paris, FRANCE
In this example, the aggregation of magnetic nanoparticles labeled with DiR is monitored in real time. Tumor microvasculature is labeled using ...
ByMauna Kea Technologies based in Paris, FRANCE
High Performance Across the Breadth of Biotech. The NX One is a perfect fit for a wide variety of sectors and application areas spanning fundamental biological research to industrial and clinical workflows. Access your cells faster and at a fraction of the ...
ByNodexus Inc. based in Hayward, CALIFORNIA (USA)
An electrical stimulation, i.e., action potential initiates cardiac contraction. Intracellular Ca2+-transient couples action potential and cardiac contraction. Cardiac contraction is also coupled to mitochondria that replenish energy (i.e., ATP) and recycle metabolites (ADP and Pi). InvivoSciences analyzes all those parameters to determine drug-induced or genetically driven changes in ECE ...
ByInvivoSciences, Inc. (IVS) based in Madison, WISCONSIN (USA)
Emission spectra were recorded in an FLS980 Fluorescence Spectrometer equipped with double excitation and emission ...
ByEdinburgh Instruments - TECHCOMP Group based in , UNITED KINGDOM
Infectious diseases are caused by pathogenic microorganisms such as bacteria, viruses, fungi or prions. Thanks to scientific advances in microbiology, host-pathogen interactions, and drug development, many of these infections can now be controlled or cured. Despite great efforts and the development of advanced technologies to investigate infectious agents, there are still many open questions regarding pathogen life cycles, how they cause disease and how can they be ...
ByONI based in Oxford, UNITED KINGDOM
Aptamers are short strands of DNA or RNA with unique secondary and tertiary structures that enable highly selective binding to various types of targets. While aptamers are similar to antibodies in their ability to specifically bind with high affinity, there are some key differences between antibodies and aptamers which have prompted an increase in aptamer development projects. Several hot areas for aptamers, along with specific aptamer advantages, are outlined below. ...
ByBase Pair Biotechnologies, Inc. based in Pearland, TEXAS (USA)
Several of the Navigo-created, ready-to-go Affilin molecules against solid tumor targets are currently developed as protein-drug conjugates (PDCs), by combining them to a half-life extending module and an engineered toxin-carrying moiety. Compared to notoriously difficult-to-produce and inhomogeneous Antibody-Drug Conjugates (ADCs), Affilin®-based PDCs have clear advantages. ...
ByNavigo Proteins GmbH based in Halle, GERMANY