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Antigen Presentation Articles & Analysis
40 articles found
These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects and complications. ...
By co-administering chemokines like CCL19 or CCL21, researchers have improved antigen presentation and immune memory in several vaccine models. Emerging Research and Challenges Recent research into chemokines has expanded beyond traditional immunology, branching into neurobiology and regenerative medicine. ...
Encapsulating anticancer drugs within its lipid bilayer improves drug accumulation in target tissues while reducing toxicity to healthy cells.Immunomodulatory TherapyFunctionalized DSPE-PEG-Mannose nanoparticles can modulate immune responses by interacting with mannose receptors on immune cells, contributing to novel treatments for immune-related disorders.Cell Recognition and SeparationBy ...
In addition, there is a growing interest in the use of liposomes as vaccine adjuvants, leveraging their immunostimulatory properties to enhance antigen presentation and elicit robust immune responses. As our understanding of the immune system and disease pathology continues to deepen, liposomes are likely to play an increasingly important role in the development ...
In addition, FcRn can also bind and promote the degradation of IgG-antigen complex multimers, enhancing the antigen presentation of antigen-presenting cells. ...
They initiate and regulate a vast array of immune responses. As potent antigen-presenting cells, DCs are capable of priming naive T cells and regulating their differentiation into effector cells. ...
In the environment of cancer, antigens may be specific to tumor cells and are known as tumor-specific antigens (TSAs) or tumor-associated antigens (TAAs). ...
Adjuvants are substances that are added to vaccines to enhance the body's immune response to the antigen (the protein that triggers an immune response). Adjuvants work by stimulating the innate immune system, which can lead to a stronger and longer-lasting immune response. ...
CpG is a type of oligodeoxynucleotide that can be used as an immune adjuvant to stimulate the maturation and development of antigen-presenting cells. CpG can be encapsulated with PLGA using the emulsion evaporation method. The tumor cell membrane expresses a large number of tumor-related antigens, so the cell membrane can be used as an ...
They initiate and regulate a vast array of immune responses. As potent antigen-presenting cells, DCs are capable of priming naive T cells and regulating their differentiation into effector cells. ...
Besides, they also can improve the antigen presenting function of dendritic cells, monocytes and macrophages, induce the proliferation of B cells, stimulate the immunoprotective activity of NK cells, and recruit T cells to the site of ODN administration. ...
On the one hand, in the presence of adjuvants, antigens are more likely to be efficiently processed and presented by antigen-presenting cells. ...
It has been reported that LNPs loaded with siRNA can be systematically delivered to the bone marrow, but passive diffusion still presents a challenge for bone-targeted drug delivery. Inspired by the fact that ligand substitution can achieve targeted LNP delivery, researchers at the University of Pennsylvania's Department of Bioengineering synthesized a series of lipids based on ...
In humans, MHC is referred to as human leukocyte antigen (HLA).Assessing Epitope Antigenicity and ImmunogenicityThe predicted immunogenicity of peptide epitopes can be analyzed through two in vivo methods: 1) in vivo immunogenicity analysis using HLA transgenic mice; 2) antigenicity testing using human ...
Due to their relatively easy uptake by antigen-presenting cells, they are commonly used in vaccines.l Neutral helper lipids, typically saturated lipids, can increase the phase transition temperature of cationic liposomes, support the formation of a lamellar lipid bilayer structure, and stabilize its structural arrangement.l Cholesterol, possessing strong membrane ...
They facilitate the recognition and binding of immune cells, such as T cells, B cells, and antigen-presenting cells, during immune responses. Neural Development: Certain Ig-superfamily CADMs are essential for neuronal development, axon guidance, and synapse formation in the nervous system. ...
The oligosaccharides that are found on the A, B, and H antigens take place on the non-reducing ends of the oligosaccharide. The H antigen (that indicates an O blood type) serves as a precursor for both the A and B antigens. Thus, a person with blood type A will have both the A antigen and H antigen ...
However, virus-infected cells or tumor cells often downregulate the expression of MHC-I to evade recognition by CD8+ cytotoxic T lymphocytes (CTLs) that rely on detecting antigen peptides presented by MHC-I. In contrast, the absence of inhibitory receptor ligands and/or upregulation of activating receptor ligands can activate NK cells, leading to their ...
It can inhibit DC differentiation and antigen presentation, induce B cell apoptosis, inhibit effector T cell proliferation, and play an immunosuppressive role. ...
DCs have several functions in the immune system depending on their level of maturity: mature DCs are mainly responsible for antigen presentation to T cells, giving DCs the common categorization of “antigen-presenting cells”. As such, they present antigens to T cells, which initiates a ...