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Aptamer Articles & Analysis
15 articles found
Development of RNA-based biosensors and methods: Recent research has concentrated on the development of biosensors and methods that detect specific molecules, such as metabolites or pathogens, by utilizing biotin-labeled RNA to form aptamers or ribozymes. Rapid diagnostics can be achieved by incorporating these RNA-based biosensors into lab-on-a-chip systems.Advantages of biotin ...
The process of QDL involves conjugating QDs to targeting molecules such as antibodies, peptides, or aptamers. These targeting molecules direct the QDs to specific structures or molecules of interest within cells or tissues. ...
Nucleic acid aptamers are single-stranded oligonucleotides with the ability to specifically bind to target molecules. ...
Understanding Aptamers Aptamers are designed to mimic the function of antibodies by recognizing and binding to target molecules, such as proteins, small molecules, or even whole cells, with exquisite specificity. ...
According to their therapeutic mechanisms, oligonucleotide drugs can be categorized into antisense oligonucleotides (ASOs), small interfering RNA (siRNA), microRNA, anti-gene transcription factor inducers, and nucleic acid aptamers. Oligonucleotide sequences typically have lengths of around 12-30 nucleotides (nucleic acid aptamers may exceed 30 nucleotides), and ...
Small nucleic acid drugs, also known as oligonucleotide drugs, include antisense nucleotides (ASO), small interfering RNA (siRNA), microRNA, nucleic acid aptamers, and others. mRNA products can be further categorized into mRNA vaccines and mRNA drugs.Characteristics of Nucleic Acid DrugsNucleic acid drugs offer distinct advantages. ...
Additionally, targeting moieties like antibodies, aptamers, or peptides can be conjugated to small molecules to achieve selective delivery to specific cellular or tissue targets, enabling personalized medicine. ...
As other roles of circRNAs continue to be revealed, applications based on circRNAs will be developed to benefit biomedical research and disease diagnosis, as well as therapeutic applications as RNA aptamers, gene expression platforms, clinical targets and biomarkers. ...
Name (Trade Name) Disease Drug Category Company Approval Year Fomvirsen(Vitravene) Tile cell virus retinitis Antisense oligonucleotide lonas Novartis 1998 Pegaptanib(Macugen) age-related macular degeneration Aptamer NeXstarEyelech 2004 Mipomersen(Kynamro) hoFH Antisense oligonucleotide loais Genryme 2013 Defibrotide(Definelio) HVOD Antisense oligonucleotide Jazz 2016 ...
In order to solve the above problems, different types of PROTAC technologies have emerged in recent years, such as Antibody-PROTAC, Aptamer-PROTAC conjugates, Dual-target PROTACs, Folate-caged PROTACs and TF-PROTACs. ...
Mango detects RNA molecules within living cells and comprises an RNA Mango aptamer that binds to a fluorescent dye. Testing brings with it other problems, including quarantine issues. ...
Though various aptamer‐based sensing methods have been developed for antibiotics, microorganisms, heavy metal ions, biotoxins, etc, there are few reports on aptamer‐based methods for quick detection of organophosphorus pesticides. ...
This paper presents a review of the use of affinity–based biosensors for the analysis of heavy metals, taking into particular account the general principles and characteristics as well as some representative applications of protein, antibody and aptamer–based biosensors. This review covers several papers published recently, highlighting the improvement reached in this field of ...
This paper presents a review about the use of electrochemical biosensors for environmental analysis, taking into particular account the general principles and characteristics as well as some representative applications of enzymatic, antibody and aptamer–based biosensors. This review covers several papers published in the last 15 years putting in evidence the improvement reached ...
Aptamers and DNAzymes are small single-stranded nucleic acids that fold into a well-defined three-dimensional structure with high specificity to various ligands, such as low-molecular-weight organic or inorganic substrates or macromolecules. ...