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Chemical Library Articles & Analysis
11 articles found
This approach involves the computational generation and optimization of novel chemical structures that are predicted to have the desired therapeutic effects. ...
These remarkable protein molecules are the unsung heroes of the biological world, orchestrating the myriad chemical reactions that sustain and power the living organisms around us. ...
The drug discovery pipeline typically begins with the identification of a disease-relevant target, followed by the screening of chemical libraries to identify lead compounds that exhibit the desired biological activity. ...
At the same time, these companies are constantly looking for new technologies for new drug development, such as high-throughput screening technology, DNA encoded chemical library, computer-aided drug discovery, and artificial intelligence. ...
In the ionizable cationic lipid chemical library synthesized by the research team, AA3 DLin LNP showed excellent mRNA delivery efficiency and long-term storage capacity (Fig. 1). ...
Virtual screening is a computer-based methodology that harnesses advanced algorithms and predictive models to analyze vast chemical libraries. It enables scientists to identify promising compounds for drug development without physically testing each one. ...
The Palpator is a high-throughput mechanical tissue analyzer that measures the mechanical properties of engineered tissues growing in 96- or 384-well plates and allows chemical library screening. IVS has carried out proof-of-concept studies to analyze the molecular mechanisms of action of different compounds on the contractile activities of different muscle ...
Many drug discovery and development recipes start the same way—with a reliable and scalable assay focused on a specific therapeutic target to search sizable chemical libraries for compounds that have the desired effects on the target. ...
In fact, most of the immediate drug discovery efforts in the early stages of the pandemic were focused on drug repurposing of known clinically approved drugs and virtual screening for the molecules available from chemical libraries. However, this method proved to be of limited efficiency. ...
A successful hit identification campaign relies on the use of a high-quality, diverse library of potential compounds to be screened, but also on capitalizing on other complementary techniques, such as structure-based virtual screening (SBVS) and fragment-based screening. ...
In this work, we have made parallel computation with a Eulerian transport/chemical model with the MPI communication library. We used two PC clusters, each PC having similar CPU and memory capacity but being connected in a network with different management systems. Three cases have been simulated, an inert one, one with a simple chemical scheme ...