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Drug Detection Articles & Analysis
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Biosensors are used in disease monitoring, drug development, and detection of pollutants, pathogenic microorganisms, and disease-indicating markers in body fluids (blood, urine, saliva, sweat). ...
Pharmaceutical manufacturers face growing challenges in ensuring product quality, maintaining regulatory compliance, and safeguarding against counterfeit drugs. Near-infrared (NIR) spectroscopy is an important tool in this arena, offering rapid, non-destructive analysis for raw material identification, impurity detection, and counterfeit screening. ...
Here are some of the most important methods for characterising doped carbon nanotubes: Transmission Electron Microscopy (TEM) and High-Resolution Transmission Electron Microscopy (HRTEM): Used to detect the structure and shape of carbon nanotubes. For instance, TEM and HRTEM can detect the dimension, dispersion and lattice fringe of doped carbon nanotubes. ...
Various functional groups or markers can be introduced into their fixed or random sequences to enhance their functions or detection effects. For example, fluorescein, biotin, magnetic beads, gold nanoparticles, etc. can be modified on nucleic acid aptamers for signal amplification or signal transduction; polyethylene glycol (PEG), cholesterol, etc. can be modified on nucleic acid ...
Therefore, intrinsic fluorescence detection is often combined with other analytical methods (such as circular dichroism, X-ray crystallography, or nuclear magnetic resonance) to obtain more comprehensive and accurate information.We offer professional intrinsic fluorescence detection services for recombinant protein drugs. In addition to providing ...
Although intrinsic fluorescence detection is a powerful tool, it also has some limitations, such as potential interference from quenchers or signal overlap when the sample contains large amounts of aromatic amino acids. Therefore, intrinsic fluorescence detection typically needs to be combined with other analytical methods (such as circular dichroism and nuclear ...
The indicator cell method uses the specific reaction of mycoplasma to certain cells, the test samples are inoculated onto the indicator cells, and the cells are observed for any corresponding changes, this method is suitable for some mycoplasmas that are difficult to culture, but the detection time required is also relatively long. The nucleic acid method is to amplify and ...
Antibody drugs, as a type of therapeutic biological preparation, require not only precise bioengineering techniques for their production but also rely on a variety of raw materials and ancillary materials to support the production and stability of the drugs. ...
Antibody drugs, as a breakthrough in biotechnology, are now widely used in the treatment of various diseases, including cancer, autoimmune diseases, and infectious diseases. ...
Recombinant protein drugs refer to protein products that originate from animals or plants and are developed through biotechnological research. These products have specific biological activity and can prevent, treat, and diagnose diseases in humans, animals, and plants. Compared with small molecule drugs, recombinant protein drugs have advantages ...
This method is suitable for some mycoplasmas that are not easy to cultivate, but the time required for detection is also relatively long. The nucleic acid method is to amplify and detect possible mycoplasmas in the drug sample, thereby judging whether the drug is contaminated. ...
However, during these production processes, some impurities are inevitably generated, posing potential threats to the efficacy and safety of the drugs. In order to ensure the quality and safety of peptide drugs, the strict detection and control of these impurities are particularly important.Sources of Impurities in Peptide DrugsImpurities related ...
Technical Process(1) Sample PreparationThe sample needs to be properly treated for subsequent mass spectrometry detection. This usually includes the purification and concentration of the sample.(2) Peptide IdentificationThe prepared sample is injected into the mass spectrometer for detection. ...
This reaction can enhance the biological activity of drugs under certain conditions, but in other circumstances, it may reduce the efficacy of drugs, and even generate toxicity.Why Should Glycosylated Impurities Be ...
In the production process of biological drugs, host cell proteins (HCPs) produced by the production cells may remain in the final drug product, and the presence of these proteins may affect the safety and effectiveness of the drug. ...
Antibody-drug conjugates (ADCs) represent a groundbreaking class of therapeutics that combine the specificity of monoclonal antibodies (mAbs) with the potent cytotoxic effects of small-molecule drugs. ...
PEGylation can significantly improve the in vivo stability of drugs, reduce the immunogenicity of protein drugs, and enhance their therapeutic effect.Services at Mtoz BiolabsThe detection methods of PEG-modified proteins include mass spectrometry, high-performance liquid chromatography, and enzyme-linked immunosorbent assay. ...
With the advancement of MS technology, we can now even detect thousands of phosphorylation sites in a single sample.In addition to MS, Western Blot is also a common technique. By using antibodies against specific phosphorylation sites, we can directly detect the phosphorylation status of target proteins. This method is suitable for specific phosphorylation ...
Data AnalysisProfessional software and databases are used to identify methylated proteins and their sites.Challenges in Detecting Protein Methylation1. Heterogeneity of ModificationsProteins can undergo mono-, di- or tri-methylation, which increases the complexity of detection.2. Detection of Low Abundance ModificationsSome methylation ...
However, the detectability of residual HCP also depends on the sensitivity of the detection method. Pharmaceutical companies often develop drug delivery methods and use a variety of technologies to evaluate all potential HCPs that may be co-produced or co-purified with drug products in the process of biological ...