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Drug Stability Articles & Analysis
97 articles found
Virus-like particles (VLPs) have garnered significant attention in recent years for their potential applications in vaccine development, drug delivery, and as tools in various biotechnological fields. These nanoparticles mimic the structure of viruses but lack the viral genetic material that makes viruses infectious. ...
These inactive substances, which are combined with the active pharmaceutical ingredient (API), perform various functions that enhance the effectiveness, stability, and overall performance of drug products. Understanding the common types of excipients is essential for pharmaceutical scientists and formulators, as it aids in the development of effective ...
As seasonal allergies affect millions globally, the demand for advanced, reliable treatments is growing rapidly. Behind the scenes of this progress lies a powerful class of materials: fluoropolymers. While often associated with aerospace, semiconductor, and chemical industries, fluoropolymers also play a vital—yet underappreciated—role in pharmaceutical manufacturing, particularly in ...
Antibody-drug conjugates (ADCs) combine potent small-molecule drugs with monoclonal antibodies for targeted cancer therapy. A major challenge is loading enough drug onto each antibody without compromising solubility or circulation time. ...
This technique improves the pharmacokinetic and pharmacodynamic properties of drugs, enhancing their stability, solubility, and circulation time while reducing immunogenicity. ...
In our last blog, Peter discussed how AI is accelerating the drug discovery process and putting pressure on chemists, who must find ways of developing these potential drugs for subsequent testing or production. ...
ByBUCHI
This article delves into the application of nitrogen compounds in antibiotic research and development, illustrating how they influence antibiotic efficac Fundamental Properties of Nitrogen Compounds Nitrogen compounds are defined as chemical substances containing nitrogen atoms within their molecular structure. In drug chemistry, these compounds are renowned for their diverse ...
Pharmaceutical manufacturers face growing challenges in ensuring product quality, maintaining regulatory compliance, and safeguarding against counterfeit drugs. Near-infrared (NIR) spectroscopy is an important tool in this arena, offering rapid, non-destructive analysis for raw material identification, impurity detection, and counterfeit screening. By integrating NIR spectroscopy into quality ...
Understanding the metabolic stability of potential drug candidates is paramount in the realm of pharmaceutical development. ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. ...
Linker Optimization: The linker serves a crucial function in maintaining stability, controlling drug release, and ensuring effective delivery of the cytotoxic drug. Linkers can be cleavable or non-cleavable, each with unique advantages and challenges. Their stability in circulation and the ability to release the ...
Diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) is a powerful analytical technique for the study of powdered and rough surface materials. It is widely employed for quality control, materials characterisation and catalytic studies in both research and industrial settings. However, optimal sample preparation and instrument setup are crucial to obtain the most reliable results ...
BySpecac
This characteristic makes them ideal for use in drug formulations that require prolonged exposure in the body. 2. Drug Loading CapacityAnother vital metric is the drug loading capacity of the copolymers. ...
The evolution of 3D printing technology has opened up new avenues in the pharmaceutical industry, especially in the fabrication of novel drug delivery systems. One such advancement is the 3D printing of Oral Thin Films (OTFs), which are ultra-thin films used to deliver drugs via oral mucosa. ...
Absorption refers to how a drug is absorbed into the bloodstream after administration. Factors influencing this process include the drug’s solubility, chemical stability, and the route of administration. ...
Optical imaging Due to the unique optical properties of gold nanoparticles, i.e., surface plasmon resonance, AuNPs can be readily used to enhance optical imaging based on their absorption, scattering, fluorescence, Raman scattering, etc. Drug delivery The application of gold nanoparticles in drug delivery is one of its most prominent characteristics. Gold ...
Antibody drugs are a kind of biological preparations that use the mechanism of the immune system to specifically recognize and bind to specific targets in the body. ...
DSC can provide vital information about protein folding and stability, which is invaluable in fields such as drug design, biotechnology, and disease research.DSC works by comparing the difference in heat flow between the sample and the reference material at the same heating rate. ...
These excipients, such as emulsifiers, thickeners, or flavoring agents, are strategically chosen to enhance stability, improve taste, or boost bioavailability. Ensuring the stability and bioavailability of the drug substance in a liquid environment remains a cornerstone of formulation science, demanding specific expertise and technological ...
In addition, the stability of nucleic acid aptamers can also be improved by introducing chemical modifications or non-natural bases, such as increasing anti-nuclease or antiserum clearance. ...