In Vivo Performance Articles & Analysis
11 articles found
In many cases, their relatively large molecular weight (usually > 1000 Da) may affect oral bioavailability, solubility, and/or in vivo pharmacokinetic properties (not conforming to the Lipinski's Rule of Five). ...
When studying the interaction interface of subunits of simple proteins or protein complexes, a suitable cross-linking agent should be selected in advance according to the structure of the target protein and the structural domain of interest. Cross-linking is performed under conditions that do not affect the normal conformation of the protein and have a high reactivity of the ...
Mesenchymal stem cells (MSCs) have shown great promise in cell therapy for various diseases, including lung injury. However, recent research has focused on the therapeutic potential of extracellular vesicles (EVs) derived from MSCs. These EVs contain bioactive molecules that can modulate immune responses and promote tissue repair. In the context of pneumonia caused by Escherichia coli (E. coli) ...
According to the article featured in the international peer-reviewed journal, BAT-90 could be considered a safe and innovative therapeutic option for unresectable solid liver tumors BetaGlue Technology’s Antonino Amato and Pier Luigi Carriero, together with Gordon McVie (King’s College London), Giovanni Paganelli (Istituto Romagnolo Studio Tumori, IRCCS), Roberto Cianni and ...
However, these perfused, vascular artificial pancreata were not successful in vivo, in part because of high rates of thrombosis of the synthetic materials used for the vascular conduit. ...
Using the test groups, it is possible to validate in vitro models and provide in vitro/in vivo correlations for the specific readouts of those models. First, appropriate readouts based on the mechanisms of gut side effects must be developed. ...
The AD-induced in vivo mouse model was performed as previously described with minor modifications (Kang et al., 2015). ...
Abstract Effect-based methods including cell-based bioassays, reporter gene assays and whole-organism assays have been applied for decades in water quality monitoring and testing of enriched solid-phase extracts. There is no common EU-wide agreement on what level of bioassay response in water extracts is acceptable. At present, bioassay results are only benchmarked against each other but not ...
We previously reported substantial differences in WF metabolism among avian species, however the actual in vivo pharmacokinetics have yet to be elucidated, even in the chicken. In the present study, we sought to provide an in‐depth characterization of WF metabolism in birds using in vivo and in vitro approaches. We performed a kinetic analysis of ...
Nanoconjugates have matured from simple devices to multifunctional, biodegradable, non–toxic and non–immunogenic constructs, capable of delivering synergistically functioning drugs in vivo. The present study evaluates the efficacy of drug polymer self folding nano–conjugates of pectin–cisplatin to enhance blood circulating levels of cisplatin. ...
The degree of dispersion of Single-Walled Carbon Nanotubes (SWCNTs) in different solvents is an issue in all studies where applications (in microelectronics, as well as in biological in vitro and in vivo systems) are envisaged. We performed long-term dispersion studies of SWCNTs in four different solvents: phosphate buffer solution (PBS), poly(sodium ...