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Lung Mechanic Articles & Analysis
13 articles found
Idiopathic pulmonary fibrosis (IPF) remains a challenging respiratory disease characterized by progressive lung scarring, with current therapies only slowing disease progression. A 2026 study of human and animal models identifies concurrent inhibition of the transcription regulators ID1 and ID3 as a potential therapeutic approach, given their upregulation in fibroblasts from ...
In the world of preclinical lung cancer research, seeing a tumor is only half the battle. While traditional imaging like microCT can show us where a mass is located, it often fails to tell the full story: How is that tumor actually affecting the animal’s ability to breathe? A recent pilot study by Smith et al (2025) has broken new ground by combining two powerhouse technologies - ...
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While ...
A recent study by Marain et al. (2025) develops a murine model to investigate the combined effects of cold air, diesel exhaust particles (DEP) and exercise on lung physiology and airway inflammation. By integrating SCIREQ’s flexiVent and Double Chamber vivoFlow+ Plethysmography, the group captures both non-invasive breathing patterns and invasive, high-resolution ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. ...
Pulmonary function tests evaluate lung function and diagnose respiratory conditions. Two critical tests of pulmonary assessment are spirometry and the measurement of diffusing capacity of the lungs for carbon monoxide (DLCO). While spirometry evaluates how effectively the lungs inhale and exhale air, DLCO assesses the lungs' ...
In a recent Nature publication by Schappe,M (2024), researchers have revealed a fascinating aspect of respiratory physiology: the role of sensory neurons in guarding against airway obstruction and orchestrating crucial reflexes to maintain respiratory function. The study explores the intricate neural pathways involved in detecting and responding to airway closure. By characterizing a ...
The chrome found in the fumes formed by welding stainless steel and released into a welder’s breathing zone is in the hexavalent state and can cause lung cancer if the welder breathes in a high enough dose of Chrome VI often enough. ...
Their children, they said, could contract lung diseases most Indian doctors would never test for, let alone treat. ...
Examples of applications are given in the context of the acute respiratory distress syndrome (ARDS), an inflammatory disease of the lung triggered by a massive arrest of white blood cells in the lung microvasculature. ...
This research aims to improve ventilation protocols in critical care by using appropriate computer models that take into account the essential lung mechanics. This paper automatically tracks the boundary of individual or groups of alveoli, and converts this into a pressure volume curve for three different types of alveoli. Schiller et al. investigate the ...
Chrome VI, on the other hand, is a well-known lung carcinogen. (DeFlora, S., “Threshold Mechanisms and Site-Specialty in Chromium (VI) Carcinogens,”Carcinogens, Volume 21, No. 4, pages 533-541, April, 2000, Oxford University Press. However, according to DeSilva, development of lung cancer “…requires massive exposures, ...
The pleura, or lining around the outside of the lungs and inside of the ribs, has some lubricating fluid. It allows the lungs and ribs to slide over each other comfortably. ...