Oral Dose Articles & Analysis
13 articles found
Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While effective, oral dosing requires high systematic concentrations, which often lead to gastrointestinal side effects and liver toxicity. ...
Rani Therapeutics, a clinical-stage biotherapeutics company, based in San Jose, CA, is developing orally-administered biologics. Their novel, patented platform technology replaces subcutaneous or IV injection of biologics with oral dosing. The RaniPill capsule is an orally ingestible vehicle, approximately the size of a standard ...
Rani Therapeutics could offer an easier alternative for people to home-dose by taking a pill instead of injections. The RaniPill capsule is the company’s patented platform technology that is designed to replace subcutaneous or IV injections of biologics with oral dosing. ...
Rani, A Platform Technology Company: Rani's proprietary platform technology, the RaniPill capsule, intends to replace subcutaneous or intravenous injections of biologics with oral dosing. RaniPill helps convert injectable biologic drugs such as TNF-alpha inhibitors, interleukin antibodies and basal insulin, among others, into pills. ...
Calves 6 weeks of age were given MgCl2 solutions by oral or rectal administration while fed diets containing either 0.04% (very deficient) or 0.24% Mg (Bacon et al, 1990). Plasma Mg of deficient calves was maximized within 10 minutes following rectal infusion compared to 160 minutes after oral dosing. However, plasma levels were sustained longer ...
For one, CBD is not very potent pharmacologically. Also, its oral bioavailability — or, the amount that enters your system by mouth — is marginal. ...
Results of simple linear regression analyses indicated that the rodent tests (rat and/or mouse) were better than the ecotoxicological tests for predicting acute oral lethal doses in man. However, it appears that the batteries of ecotoxicological tests resulting from the partial least squares method appear to be better than the rodent tests for predicting human ...
Excretion of radioactivity was rapid with nearly all of the dose recovered within 48 h post dose. Feces was the major route of excretion accounting for? ...
While potency is not relevant for identification of a compound as an endocrine disruptor, there may be high doses (e.g., the oral toxicity limit of 1,000 milligram per kilogram (mg/kg) body weight per day) above which identification as an endocrine disruptor would not be warranted. ...
Plasma and brain cholinesterase activity in relation to time since exposure to pesticide were also determined. An orally applied dose of 90 mg kg−1 fenitrothion reduced running endurance in the stripe‐faced dunnart, Sminthopsis macroura, by 80% the day after exposure concomitantly with a reduction of approximately (∼) 50% in plasma and 45% in brain ...
The goal of this research was threefold: to improve oral and dermal dosing methodologies for reptiles, to generate reptile toxicity data for pesticides, and to correlate reptile and avian toxicity. ...
Twenty five-week old hens (n = 6) were administered with an oral dose of 75 mg of Oxytetracycline (OTC) hydrochloride per day per head for five consecutive days and its residues in eggs as well as breast, leg and liver tissues were analysed by a high-performance liquid chromatography-ultraviolet visible detection (HPLC-UV) technique. The highest OTC residue ...
The highest concentration of each pesticide corresponded to the median lethal dose value (48-h oral LD50), received per bee and per day, divided by 20. ...